Antioxidant and Cytotoxic Potential of Local Endemic Plant Pastinaca zozimoides Fenzl

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dc.contributor.authorDüşgün, Cihan
dc.contributor.authorKankılıc, Teoman
dc.contributor.authorİşlek, Cemil
dc.contributor.authorBalı, Dilara Fatma
dc.contributor.authorKankılıç, Özgür
dc.date.accessioned2024-11-07T13:16:28Z
dc.date.available2024-11-07T13:16:28Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractP. zozimoides is local endemic in Nigde province, Turkey. There has been no previous examination of the chemical composition and bioactivity of that plant extract. In this study, we studied total phenolic content, antioxidant properties and cytotoxic effect of methanolic extracts of plant sample. According to the Folin-Ciocalteau method, the total phenolics of the extracts were determined spectrophometric. The antioxidant activity was conducted DPPH (1,1’-diphenyl-2-picrylhydrazyl) radical scavenging method and free radical reducing power assay. The cytotoxic effect was studied using MTT assay cell viability on cancer cell lines as well as on Caco-2 cell lines. The total phenolic content of P. zozimoides extract was found 28.79±0.68 ?g GAE /mg. The free radical scavenger activities of the DPPH was 31.69%±1.61, 85.15%±0.13, 86.96%±0.085 for 1, 5 and 10 mg/mL, respectively. The free radical reducing power assay was 0.375±0.52, 1.587±0.71, 1.798±0.84 for 1, 5 and 10 mg/mL compared to ascorbic acid standard. On Caco-2 cell lines, the extract of plant showed no cytotoxic potential. Because of its phenolic constituents and its antioxidant capacity it can be considered a healthy nutrient.
dc.identifier.doi10.24925/turjaf.v9i4.646-649.3715
dc.identifier.endpage649
dc.identifier.issn2148-127X
dc.identifier.issue4
dc.identifier.startpage646
dc.identifier.trdizinid463180
dc.identifier.urihttps://doi.org/10.24925/turjaf.v9i4.646-649.3715
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/463180
dc.identifier.urihttps://hdl.handle.net/11480/12344
dc.identifier.volume9
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTürk Tarım - Gıda Bilim ve Teknoloji dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241107
dc.subjectBiyoloji
dc.subjectKimya
dc.subjectTıbbi
dc.titleAntioxidant and Cytotoxic Potential of Local Endemic Plant Pastinaca zozimoides Fenzl
dc.typeArticle

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