Genetic and epigenetic concept of SARS-CoV-2 targets in different renal cancer subtypes

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dc.authoridIlikci Sagkan, Rahsan/0000-0003-3844-6158
dc.contributor.authorAkin-Bali, Dilara Fatma
dc.contributor.authorSagkan, Rahsan Ilikci
dc.date.accessioned2024-11-07T13:32:23Z
dc.date.available2024-11-07T13:32:23Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjectives: Recent advances in defining the genetic landscape of has shown the host cell-SARS-CoV-2 interaction via ACE2 protein and the presence of at least three additional virus invasion genes including TMPRSS2, FURIN, CD147/BSG. In current study, we investigated the mutation and m-RNA expression patterns of target genes by evaluating the associations between genetic and epigenetic mechanisms in the target genes and susceptibility of SARS-CoV-2 infection of renal cancer subtypes. Methods: We investigated the mutation and m-RNA expression patterns of our target genes. The promoter methylation profiles of target genes were tested in the UALCAN database. Results: The total rate of carrying genetic anomaly in the target genes including was 1.6% and seven mutations, one of which had a pathogenic feature, were detected. The expression analysis results in renal cancer groups showed that while the KIRC and KIRP patients had a lower level of TMPRSS2 than the healthy control, their ACE2 level was high. KICH patients had a higher level of CD147/BSG expression than the healthy group. The promoter methylation levels of ACE2 in KIRC and KIRP were reduced. Conclusions: We concluded that renal cancer patients may be more sensitive to SARS-CoV-2 infection, which may worsen the prognosis.
dc.identifier.doi10.1515/tjb-2020-0233
dc.identifier.endpage155
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85106214090
dc.identifier.scopusqualityQ4
dc.identifier.startpage145
dc.identifier.trdizinid492670
dc.identifier.urihttps://doi.org/10.1515/tjb-2020-0233
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/492670
dc.identifier.urihttps://hdl.handle.net/11480/15379
dc.identifier.volume46
dc.identifier.wosWOS:000646210300004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectACE2
dc.subjectCD147/BSG
dc.subjectCOVID-19
dc.subjectFURIN
dc.subjectmethylation
dc.subjectrenal cancer
dc.subjectSevere acute respiratory syndrome coronavirus 2
dc.subjectTMPRSS2
dc.titleGenetic and epigenetic concept of SARS-CoV-2 targets in different renal cancer subtypes
dc.title.alternativeFarklı böbrek kanseri alt tiplerinde SARS-CoV-2 hedeflerinin genetik ve epigenetik konsepti
dc.typeArticle

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