Serum and salivary obestatin concentrations in thediagnosis of polycystic ovary syndrome

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dc.contributor.authorYavuz, Adem
dc.contributor.authorAydin, Suleyman
dc.contributor.authorGurates, Bilgin
dc.date.accessioned2024-11-07T13:19:28Z
dc.date.available2024-11-07T13:19:28Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAim: : To measure obestatin levels in the blood and saliva samples of normal-weight patients with polycystic ovary syndrome(PCOS) in comparison with normal-weight healthy controls, and to determine whether there were relationships between blood and/or salivary obestatin levels and other measured parameters.Materials and Methods: Fifteen healthy women and 15 patients with PCOS, all of which had normal weight, were included in thestudy. Participants’ age, height, weight, menstrual characteristics, hormone levels, body mass index, waist/hip ratio, and modified Ferriman-Gallwey (FG) scores were recorded. Obestatin levels were measured in both fasting blood and saliva samples. Homeostasis Model Assessment (HOMA-IR) was used to predict insulin resistance.Results: In the PCOS group, menstrual cycle duration and FG scores were significantly higher (P-value, <0.001, <0.001, respectively).The levels of luteinizing hormone, total testosterone and androstenedione were significantly higher in the PCOS group than in the control group (P-value, 0.001, 0.009, 0.004, respectively). In the PCOS group, blood obestatin level was 1265.2 ± 221.9 pg/ml, salivary obestatin level was 3095.33 ± 310.2 pg/ml; whereas the control group demonstrated lower levels of 939.66 ± 72.3 pg/ml and 2611.20 ± 217.1 pg/mL, respectively. However, no statistically significant difference was found between the PCOS and control groups when comparing obestatin levels in blood or saliva (P-value, 0.218, 0.369, respectively). No correlation was found between blood and salivary obestatin levels in either group. Finally, obestatin levels were not associated with any of the other measured parameters.Conclusion: Our results suggest that increased levels of obestatin, albeit in a small amount that would not be statistically significantin normal weight patients with PCOS, may have significant effects on weight control in these patients. In addition, our findings show that saliva sample can be used as an alternative to blood sample in the measurement of obestatin level in patients with PCOS.
dc.identifier.doi10.5455/annalsmedres.2020.10.1038
dc.identifier.endpage1028
dc.identifier.issn2636-7688
dc.identifier.issue5
dc.identifier.startpage1024
dc.identifier.trdizinid468507
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2020.10.1038
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/468507
dc.identifier.urihttps://hdl.handle.net/11480/13150
dc.identifier.volume28
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofAnnals of Medical Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241107
dc.subjectKadın Hastalıkları ve Doğum
dc.subjectKimya
dc.subjectTıbbi
dc.titleSerum and salivary obestatin concentrations in thediagnosis of polycystic ovary syndrome
dc.typeArticle

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