Effect of N-acetylcysteine on cisplatin induced apoptosis in rat kidney

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dc.authoridYAZICI, Cevat/0000-0003-0625-9542
dc.contributor.authorGunturk, Inayet
dc.contributor.authorSeydel, G. Seyda
dc.contributor.authorDagli, Fatma
dc.contributor.authorYay, Arzu
dc.contributor.authorYazici, Cevat
dc.contributor.authorKose, Kader
dc.date.accessioned2024-11-07T13:23:55Z
dc.date.available2024-11-07T13:23:55Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description27th Congress of the Balkan-Clinical-Laboratory-Federation (BCLF) / 30th National Biochemistry Congress (NBC) -- OCT 27-31, 2019 -- Antalya, TURKEY
dc.description.abstractPurpose: Cisplatin is one of the most potent and widely used chemotherapeutic agents for the treatment of a wide variety of solid organ cancers. However, due to various side-effects such as nephrotoxicity, its therapeutic applications are limited. In the current study, it was aimed to investigate the effects of N-acetylcysteine (NAC), which is an effective antioxidant and anti-inflammatory agent, on cisplatin-induced apoptosis in rat kidneys. Materials and Methods: Twentyfour male Wistar rats were separated into 4 equal groups: Control, NAC-250, cisplatin (CP), and CP+NAC groups. Rats in the experimental groups were treated with intraperitoneally (i.p.) single-dose cisplatin (10 mg/kg) and NAC (i.p., 250 mg/kg) for 3 days. Results: At the end of the experiment, nephrotoxicity was confirmed by blood urea nitrogen and creatinine levels, and the apoptotic changes were demonstrated by TdT-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) and caspase-3 levels in rat kidneys. The number of TUNEL-positive cells and caspase-3 levels were significantly increased by cisplatin. Treating the rats with NAC significantly decreased TUNEL-positive cells and caspase-3 levels. Conclusion: These data suggest that apoptotic cell death is involved in the pathogenesis of cisplatin-induced nephrotoxicity, and that the inhibition of apoptosis plays a central role in the beneficial effects of NAC.
dc.description.sponsorshipBalkan Clin Lab Federat
dc.description.sponsorshipResearch Fund of Erciyes University [TDK-2014-5056]
dc.description.sponsorshipThis study was supported by the Research Fund of Erciyes University (Grant No: TDK-2014-5056) .
dc.identifier.doi10.17826/cumj.783088
dc.identifier.endpage525
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue2
dc.identifier.startpage519
dc.identifier.trdizinid524608
dc.identifier.urihttps://doi.org/10.17826/cumj.783088
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/524608
dc.identifier.urihttps://hdl.handle.net/11480/13800
dc.identifier.volume47
dc.identifier.wosWOS:000815481700006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherCukurova Univ, Fac Medicine
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectCisplatin
dc.subjectapoptosis
dc.subjectN-acetylcysteine
dc.subjectRat
dc.subjectTUNEL
dc.titleEffect of N-acetylcysteine on cisplatin induced apoptosis in rat kidney
dc.typeConference Object

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