Efficacy of Daptomisin Versus Linezolid in the Treatment of Vancomycin Resistant Enterococcus Meningitis in an Experimental Rabbit Model
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkiye Klinikleri
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Acute bacterial meningitis, which has a high rate of mortality and morbidity, has emergency therapy indication. Optimal therapy must be applied at optimal duration and optimal dosage. Carriage of vancomycin resistant enterococcus (VRE) are increasingly seen and we see VRE as the cause of postoperative meningitis. How-ever, in VRE meningitis, there is no optimal treatment regimen and the disease is evaluated on a case-by-case basis. In this study, it is aimed to contribute to a treatment plan for VRE meningitis based on the experimental meningitis model. Material and Methods: In our study, after creating a VRE experimental meningitis model, daptomycin and linezolid activity was compared with control group. Daptomycin was given 15 mg/kg at one dose, linezolid was given 20 mg/kg at 2 doses every 12 hours. Groups were compared with each other for cerebrospinal fluid (CSF) cell count, culture, protein, glucose, simultaneous blood glucose. Results: In both groups, CSF pleocytosis and biochemical response were similar. In the daptomycin group 24th hour of the treatment, CSF culture was positive in 22% of the rabbits, whereas no growth was observed in linezolid and control groups. Conclusion: As a result, there is no statistically significant difference observed between daptomycin and linezolid groups. There is not a standard treatment regimen for VRE meningitis, so we couldn’t compare the antibiotics that we use in our study with the standard regimen. Due to the lack of an established treatment regimen for VRE meningitis, it was not possible to compare the efficacy of antibiotics in our study with the standard regimen. Further research should be conducted on new antibiotics, combination therapies and intrathecal-intraventricular practices. © 2023 by Türkiye Klinikleri.
Açıklama
Anahtar Kelimeler
daptomycin, linezolid, Meningitis, vancomycin resistant enterococcus
Kaynak
Turkiye Klinikleri Journal of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
43
Sayı
3
