Transportation of Poorly Soluble Drug Molecules from the Organic Phase to the Aqueous Phase by Using Phosphorylated Calixarenes
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Date
2011
Journal Title
Journal ISSN
Volume Title
Publisher
AMER CHEMICAL SOC
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
This study is the first report on the extraction of poorly soluble drug molecules such as nifedipine, niclosamide, and furosemide from the organic phase to the aqueous phase by water-soluble p-phosphonate calix[n]arene receptors via a liquid-liquid phase extraction process. These water-soluble calixarene derivatives were easily obtained from the reaction between their corresponding chloromethylated derivatives and trimethyl phosphite. From the liquid-liquid phase extraction studies, it was observed that the size of the p-phosphonate calix[n]arenes changed the extraction percentage of selected drug molecules.
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Keywords
Journal or Series
JOURNAL OF CHEMICAL AND ENGINEERING DATA
WoS Q Value
Q2
Scopus Q Value
Q2
Volume
56
Issue
12
