Structural Analysis of Novel Amino Acid Substitutions in SARS-CoV-2 Spike Protein Receptor-Binding Domain

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dc.contributor.authorSüt, Burcu Biterge
dc.date.accessioned2024-11-07T13:15:56Z
dc.date.available2024-11-07T13:15:56Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractT here are several novel amino acid substitutions in SARS-CoV-2 spike protein, which could account for the increased infec- tivity of this newly emerged virus. Therefore, in this paper we aimed to evaluate the potential effects of these amino acid substitutions on protein structure and function. For this purpose, we made use of several state-of-the-art computational tools and performed in silico analyses on protein similarity, 2D and 3D structure, ligand binding and biological function. We found that some of the novel amino acid changes caused significant structural alterations both at the secondary and terti - ary structure level, possibly affecting the interaction between the spike protein receptor-binding domain (RBD) and ACE2, as well as other ligands. In conclusion, data we provided here is a significant contribution to our current knowledge of the SARS-CoV-2 virus and will aid in having a better understanding of its molecular differences, mechanism of infection and the cellular processes it affects in the host in order to develop better therapies and vaccines.
dc.identifier.doi10.15671/hjbc.776430
dc.identifier.endpage374
dc.identifier.issn1303-5002
dc.identifier.issn2687-475X
dc.identifier.issue4
dc.identifier.startpage367
dc.identifier.trdizinid483842
dc.identifier.urihttps://doi.org/10.15671/hjbc.776430
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/483842
dc.identifier.urihttps://hdl.handle.net/11480/11966
dc.identifier.volume49
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofHacettepe Journal of Biology and Chemistry
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241107
dc.subjectViroloji
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.subjectHücre Biyolojisi
dc.titleStructural Analysis of Novel Amino Acid Substitutions in SARS-CoV-2 Spike Protein Receptor-Binding Domain
dc.typeArticle

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