DTI Measurements for Huntington Disease Using Mricloud

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dc.contributor.authorArslan, Ayla
dc.contributor.authorNisari, Mehtap
dc.contributor.authorGüler, Emel
dc.contributor.authorUzun, Gökçe Bağcı
dc.contributor.authorGültekin, Murat
dc.contributor.authorDönmez, Halil
dc.contributor.authorBağcı, Keziban
dc.date.accessioned2024-11-07T13:19:18Z
dc.date.available2024-11-07T13:19:18Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAim: Neurodegenerative diseases are important health problems that affect many people. In this study, it was aimed to examine the brain regions of Huntington's patients by performing brain parcellation. Material and Method: 8 controls and 8 Huntington's patients participated in the study. We measured four Diffusion Tensor Imaging metrics which were axial diffusivity, mean diffusivity, radial diffusivity and fractional anisotropy performing brain parcellation over Diffusion Tensor Imaging for control and patient groups. We used a full automated data-driven approach to study the whole brain, divided in regions of interest using mricloud. Results: When the huntington disease group compared to control group, We found that mean diffusivity and axial diffusivity increased frontal, parietal, temporal, occipital, corpus callosum, white matter, limbic and subcortical structures, and radial diffusivity increased corpus callosum, capsula interna (p<0.05). The fractional anisotropy value was higher in nucleus caudatus, putamen and a significant difference was observed (p<0.05). Conclusion: The increase of axial diffusivity and mean diffusivity values axonal degeneration and demyelination of frontal, parietal, temporal, occipital, corpus callosum, white matter, limbic, subcortical structures; increased radial diffusivity values dysmyelination of the corpus callosum and capsula interna; fractional anisotropy increased values in nucleus caudatus and putamen may indicate a degenerative process, axon loss and inflammation.
dc.identifier.doi10.37990/medr.1421420
dc.identifier.endpage311
dc.identifier.issn2687-4555
dc.identifier.issue2
dc.identifier.startpage302
dc.identifier.trdizinid1259711
dc.identifier.urihttps://doi.org/10.37990/medr.1421420
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1259711
dc.identifier.urihttps://hdl.handle.net/11480/13012
dc.identifier.volume6
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofMedical records-international medical journal (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241107
dc.subjectMikroskopi
dc.subjectMatematik
dc.subjectKlinik Nöroloji
dc.subjectNörolojik Bilimler
dc.subjectJeoloji
dc.subjectFizik
dc.subjectPartiküller ve Alanlar
dc.subjectPsikiyatri
dc.subjectMagnetic resonance imaging
dc.subjectbrain
dc.subjectHuntington disease
dc.subjectneurodegenerative disease
dc.titleDTI Measurements for Huntington Disease Using Mricloud
dc.typeArticle

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