Nephrological factors may cause kidney dysfunction in patients with common variable immunodeficiency

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dc.contributor.authorAytekin, Gökhan
dc.contributor.authorBaloğlu, İsmail
dc.contributor.authorÇölkesen, Fatih
dc.contributor.authorYildiz, Eray
dc.contributor.authorArslan, Şevket
dc.contributor.authorTürkmen, Kültigin
dc.date.accessioned2024-11-07T10:39:47Z
dc.date.available2024-11-07T10:39:47Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground/aim: Common variable immunodeficiency (CVID) is a heterogeneous primary deficiency characterized by hypogammaglobulinemia, recurrent infections, an increased risk of autoimmune disease, malignancy, and chronic inflammation. Proteinuria is one of the most important prognostic factors causing progression in kidney disease. Proteinuria causes tubulotoxicity, activates inflammatory markers that cause fibrosis, and consequently nephropathy progression. The data is scant in the literature regarding the inflammation and nephropathy in CVID. Hence, in the present study, we aimed to investigate the relationship between tubular dysfunction, proteinuria, and inflammation in patients with CVID. Materials and methods: This was a cross-sectional study involving 27 patients with CVID (15 females, 12 males; mean age, 39.88 ± 13.47 years) and 18 control subjects (10 females, 8 males; mean age, 33.83 ± 7.97 years). Patients were evaluated for kidney functions including glomerular filtration rate, fractional excretion of sodium, metabolic acidosis, serum/urine anion gap, 24-h urine proteinuria and, were grouped in terms of proteinuria. Blood samples obtained from the patients with CVID were taken into 2 mL EDTA tube to evaluate peripheral NK cell subgroups according to CD56 and CD16 expression and CD3, CD4, CD 8 expression to determine subtypes T cells. These cells were evaluated by flow cytometry technique. Results: Urinary density, fractional excretion of sodium, proteinuria, and metabolic acidosis are found to be higher in patients with CVID when compared to healthy controls. In the bivariate correlation analysis, proteinuria was positively correlated with age (r = 0.496, p = < 0.001), CD8+T cells percentage (r = 0.427, p = 0.02). Albumin, CRP, and CD8+T cell percentage were found to be independent variables of proteinuria. Conclusion: Increased chronic ongoing inflammation was found to be associated with proteinuria in patients with CVID. Hence, in routine outpatient clinics, proteinuria should not be overlooked in this group of patients. © TÜBİTAK.
dc.identifier.doi10.3906/sag-2012-166
dc.identifier.endpage1931
dc.identifier.issn1300-0144
dc.identifier.issue4
dc.identifier.pmid33843169
dc.identifier.scopus2-s2.0-85114266158
dc.identifier.scopusqualityQ3
dc.identifier.startpage1924
dc.identifier.trdizinid480643
dc.identifier.urihttps://doi.org/10.3906/sag-2012-166
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/480643
dc.identifier.urihttps://hdl.handle.net/11480/11213
dc.identifier.volume51
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkiye Klinikleri
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectChronic inflammation
dc.subjectCommon variable immunodeficiency
dc.subjectProteinuria
dc.titleNephrological factors may cause kidney dysfunction in patients with common variable immunodeficiency
dc.typeArticle

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