Antioxidant and Antigenotoxic Potential of Infundibulicybe geotropa Mushroom Collected from Northwestern Turkey

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dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.authoridBraidy, Nady/0000-0002-0497-5572
dc.contributor.authorSevindik, Mustafa
dc.contributor.authorAkgul, Hasan
dc.contributor.authorSelamoglu, Zeliha
dc.contributor.authorBraidy, Nady
dc.date.accessioned2024-11-07T13:35:01Z
dc.date.available2024-11-07T13:35:01Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractInfundibulicybe geotropa (Bull.) Harmaja is an edible mushroom found in Bolu province in northwestern Turkey. The chemical composition and bioactivity of these mushrooms has not been previously investigated. We examined the phenolic composition, elemental content, and antioxidant and antigenotoxic effects of methanol extracts of fruiting bodies. The phenolic compounds in the fungal samples were determined using high-performance liquid chromatography (HPLC), and element content was determined using atomic absorption spectrophotometry. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were determined using the commercially available Rel assay kit. The antigenotoxic effects of the extract were determined using the MTT assay to assess cell viability and the alkaline single-cell gel electrophoresis assay (Comet assay). The total phenolic content (ppm) of I. geotropa was found to be catechin (361 +/- 2.31), clorogenic acid (553.54 +/- 5.06), and coumaric acid (9.93 +/- 0.25). The TAS, TOS, and OSI of the extract were 1.854 +/- 0.051 mmol/L, 30.385 +/- 0.399 mu mol/L, and 1.639 +/- 0.067, respectively. The elemental levels were within normal range. In HT22 mouse hippocampal neuronal cells, the extract (100 and 200 mu g/ml) showed no genotoxic potential and ameliorated hydrogen peroxide- (H2O2-) induced oxidative DNA damage. I. geotropa may be considered a good nutrient due to its phenolic constituents and antioxidant potential.
dc.description.sponsorshipTUBITAK
dc.description.sponsorshipThe study was supported by TUBITAK. There is no financial disclosure for the current study. We would like to express our gratitude to Dr. Ilgaz AKATA for his contribution to the present study.
dc.identifier.doi10.1155/2020/5620484
dc.identifier.issn1942-0900
dc.identifier.issn1942-0994
dc.identifier.pmid32148651
dc.identifier.scopus2-s2.0-85081172209
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1155/2020/5620484
dc.identifier.urihttps://hdl.handle.net/11480/16283
dc.identifier.volume2020
dc.identifier.wosWOS:000519051800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHindawi Ltd
dc.relation.ispartofOxidative Medicine and Cellular Longevity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectCulinary-Medicinal Mushrooms
dc.subjectRadical Scavenging Activity
dc.subjectAge-Related Diseases
dc.subject3 Edible Mushrooms
dc.subjectOxidative Stress
dc.subjectChemical-Composition
dc.subjectVolatile Composition
dc.subjectMetal Concentration
dc.subjectHealth-Benefits
dc.subjectExtracts
dc.titleAntioxidant and Antigenotoxic Potential of Infundibulicybe geotropa Mushroom Collected from Northwestern Turkey
dc.typeArticle

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