Investigation of Cytokines, Biochemical Parameters and Oxidative Stress Levels in Serum of Patients with Acute Pancreatitis

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dc.contributor.authorBayraktar, Nihayet
dc.contributor.authorAslan, Oruç
dc.contributor.authorUyanıkoğlu, Ahmet
dc.contributor.authorÖztürk, Ali
dc.contributor.authorBayraktar, Mehmet
dc.contributor.authorErdoğdu, Hamza
dc.date.accessioned2024-11-07T13:19:27Z
dc.date.available2024-11-07T13:19:27Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjective: This study aimed to find new serum biochemistry parameters, especially for the early identification of severe AP. In the study serum cytokine levels (TNF-A, IL-1, IL-6, IL-10, IL-21), biochemical parameters (Aquaporin-1, Hepcidine, Iron, Zinc, Copper, Nitric Oxide, C-Reactive protein), and oxidative stress parameters analysis were performed. Method: A total of 46 patients with AP and 46 healthy controls were included in this study. Serum cytokine levels, biochemical, and oxidative stress parameters by the ELISA method, and CRP by the immunoturbidimetric method were measured. Results: When patients with AP and control groups were compared, all studied parameters were found to be statistically significant (p<0.05). However, IL-1 was found to be insignificant (p>0.05). Therefore, the Mann-Whitney U test, which is a non-parametric test, was found suitable to determine whether there was a significant difference between the patient and control groups. Conclusions: Investigating the role of cytokines, oxidative stress and other biochemical parameters in the pathogenesis and course of the disease may contribute to a better understanding of the disease process and its therapeutic value. It showed a significant increase in oxidative stress parameters and biochemical parameters such as aquaporin-1, hepcidin, lipase, and amylase, which may help in the diagnosis of AP.
dc.identifier.doi10.54005/geneltip.1264527
dc.identifier.endpage165
dc.identifier.issn2602-3741
dc.identifier.issue2
dc.identifier.startpage158
dc.identifier.trdizinid1232855
dc.identifier.urihttps://doi.org/10.54005/geneltip.1264527
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1232855
dc.identifier.urihttps://hdl.handle.net/11480/13126
dc.identifier.volume34
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofGenel Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241107
dc.subjectGenel ve Dahili Tıp
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.subjectHücre Biyolojisi
dc.subjectTıbbi Laboratuar Teknolojisi
dc.subjectCerrahi
dc.subjectOxidative stress
dc.subjectAcute pancreatitis
dc.subjectcytokine
dc.subjectsome other biochemical parameters
dc.titleInvestigation of Cytokines, Biochemical Parameters and Oxidative Stress Levels in Serum of Patients with Acute Pancreatitis
dc.typeArticle

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