Assessment of the Relationship Between the Adropin Levels and the Coronary Collateral Circulation in Patients with Chronic Coronary Syndrome

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dc.authoridAKKAYA, HASAN/0000-0003-0853-2549
dc.authoridkarabiyik, ugur/0000-0002-5644-751X
dc.authoridYilmaz, Samet/0000-0003-4738-3478
dc.authoridGunturk, Inayet/0000-0002-8299-1359
dc.contributor.authorAkkaya, Hasan
dc.contributor.authorGunturk, Ertugrul Emre
dc.contributor.authorAkkaya, Fulya
dc.contributor.authorKarabiyik, Ugur
dc.contributor.authorGunturk, Inayet
dc.contributor.authorYilmaz, Samet
dc.date.accessioned2024-11-07T13:25:08Z
dc.date.available2024-11-07T13:25:08Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground: Coronary collateral circulation (CCC) provides an alternative blood flow to myocardial tissue exposed to ischemia and helps to preserve myocardial functions. Endothelial-derived nitric-oxide (NO) production and vascular endothelial growth factor (VEGF) have been suggested as the most important factors in the development of CCC. Adropin is a peptide hormone responsible for energy hemostasis, and is known for its positive effects on the endothelium through NO and VEGF. Objective: The aim of this study is to investigate the association between adropin and the presence of CCC in patients with chronic coronary syndrome (CCS). Methods: A total of 102 patients with CCS, who had complete occlusion of at least one major epicardial coronary artery, were included in the study and were divided into two groups: the group of patients (n:50) with poor CCC (Rentrop 0-1) and the group of patients (n:52) with good CCC (Rentrop 2-3). The level of significance adopted in the statistical analysis was 5%. Results: Mean adropine levels were found as 210.83 +/- 17.76 pg/mL and 268.25 +/- 28.94 pg/mL in the poor and good CCC groups, respectively (p<0.001). Adropin levels proved to be positively correlated with neutrophil-to-lymphocyte ratios (r:0.17, p:0.04) and the rentrop scores (r:0.76, p<0.001), and negatively correlated with age (r:-0.23, p:0.01) and Gensini scores (r:-0.19, p:0.02). Adropin level is a strong independent predictor of good CCC development (OR:1.12, 95% CI:(1.06-1.18), p<0.001). Conclusion: This study suggests that adropin levels may be a possible factor associated with the presence of CCC in CCS patients.
dc.identifier.doi10.36660/abc.20210573
dc.identifier.endpage410
dc.identifier.issn0066-782X
dc.identifier.issn1678-4170
dc.identifier.issue3
dc.identifier.pmid35766616
dc.identifier.scopus2-s2.0-85137078048
dc.identifier.scopusqualityQ3
dc.identifier.startpage402
dc.identifier.urihttps://doi.org/10.36660/abc.20210573
dc.identifier.urihttps://hdl.handle.net/11480/14533
dc.identifier.volume119
dc.identifier.wosWOS:000854003100009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherArquivos Brasileiros Cardiologia
dc.relation.ispartofArquivos Brasileiros De Cardiologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectAcute Coronary Syndrome
dc.subjectAtherosclerosis
dc.subjectPeptides
dc.subjectAdropin
dc.subjectCoronary Artery Diseases
dc.subjectCoronary Collateral Circulation
dc.subjectDiagnostic Imaging
dc.subjectCoronary Angiography
dc.titleAssessment of the Relationship Between the Adropin Levels and the Coronary Collateral Circulation in Patients with Chronic Coronary Syndrome
dc.title.alternativeAvaliação da Relação entre Níveis de Adropina e Circulação Colateral Coronária em Pacientes com Síndrome Coronariana Crônica
dc.typeArticle

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