Mutations and Expression Profile of EDIL3 and Correlation with HIF1A and Tumor-Associated Carbonic Anhydrases in Pancreatic Cancer

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dc.authoridIlikci Sagkan, Rahsan/0000-0003-3844-6158
dc.contributor.authorBali, Dilara Fatma Akin
dc.contributor.authorSagkan, Rahsan Ilikci
dc.date.accessioned2024-11-07T13:25:24Z
dc.date.available2024-11-07T13:25:24Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjective: Epidermal growth factor-like repeats and discoidin I-like domains 3 (EDIL3) expression is upregulated in some types of cancer which means that it can be used as a candidate tumor marker. The expression level of EDIL3 as a marker of the hypoxic microenvironment of pancreatic cancer was assessed by studying its relationship with the expression of tumor-associated carbonic anhydrases (CA IX and CA XII) and Hypoxia-inducible factor-1 (HIF-1) in tumor development. Methods: Gene expression and mutation profiles of pancreatic cancer patients and healthy tissue samples were downloaded The Cancer Genome Atlas (TCGA), and the genetic alterations and expression levels of the EDIL3, HIF-1 alpha, CA IX and CA XII genes were analyzed. Additionally, PolyPhen-2 and SNAP tools were used to prediction and confirmation of detected alterations pathogenicity and survival analysis was performed. Results: Expression levels of EDIL3, HIF-1 alpha and CA IX were found to be statistically significant higher in the patient compared to healthy group and we showed also positive correlation between EDIL3 and HIF-1 alpha gene expression. Furthermore, low CA IX and CA XII expression levels were found effective on overall survival (p<0.05). Additionally, 8 missense mutations were detected in the coding region of studied genes. Conclusion: We suggested that relationship between EDIL3 and HIF-1 alpha in pancreatic cancer and EDIL3 is a novel molecule cancer development in pancreatic cancer.
dc.identifier.doi10.33808/clinexphealthsci.756701
dc.identifier.endpage425
dc.identifier.issn2459-1459
dc.identifier.issue3
dc.identifier.startpage418
dc.identifier.trdizinid481017
dc.identifier.urihttps://doi.org/10.33808/clinexphealthsci.756701
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/481017
dc.identifier.urihttps://hdl.handle.net/11480/14667
dc.identifier.volume11
dc.identifier.wosWOS:000706782100008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherMarmara Univ, Inst Health Sciences
dc.relation.ispartofClinical and Experimental Health Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectCAs
dc.subjectEDIL3
dc.subjectHIF-1 alpha
dc.subjectmutation
dc.subjectexpression
dc.subjectpancreatic cancer
dc.titleMutations and Expression Profile of EDIL3 and Correlation with HIF1A and Tumor-Associated Carbonic Anhydrases in Pancreatic Cancer
dc.typeArticle

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