Association of IL-4 and IL-1 Ra Gene Polymorphisms with the Risk of Bladder Cancer

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dc.contributor.authorPolat, Fikriye
dc.contributor.authorBingöl, Günsel
dc.contributor.authorDiler, Songül Budak
dc.date.accessioned2024-11-07T13:16:17Z
dc.date.available2024-11-07T13:16:17Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThe aim of this study is to evaluate the association of interleukin-4 (IL-4) gene intron 3 and interleukin-1 receptor antagonist (IL-1Ra) gene intron 2 variable number tandem repeat (VNTR) polymorphisms with bladder cancer (BC) susceptibility in Turkish population. A total of 75 BC patients and 126 healthy controls were included in this case-control study. Genotyping for the interested polymorphisms were analyzed through polymerase chain reaction (PCR). The strength of association between both IL-4 and IL-1Ra gene VNTRs and BC susceptibility was estimated utilizing odds ratio (OR) with corresponding 95% confidence interval (CI). In the study, no statistically significant differences were determined in the allele distributions for either in IL-4 gene intron 3 VNTR (OR= 1.33; CI 0.704-2,41, p=0.390) or in IL-1Ra gene intron 2 VNTR polymorphisms (OR= 0.890; CI 0.569-1.394, p=0.346) between BC patients and control groups. The genotype distributions of IL-4 gene were estimated for RP1/RP2 (OR= 1.55; CI 0.11-7.74, p = 0.590) and RP1/RP1 (OR= 2.08; CI 0.48-9.06, p = 0.320), found no difference between BC and control groups. The genotype distributions of IL-1Ra gene were estimated for 2L (OR= 1.401; CI 0.753-2.610, p = 0.287) and 22 (OR=0.908; CI 0.252-3.276, p = 0.883) and found no difference between BC and control groups. This study suggest that there were no statistically significant differences determined either in genotype or allele distributions between BC patients and control groups for both IL-4 intron 3 VNTR and IL-1Ra intron 2 VNTR polymorphisms in Turkish population and therefore there was no association of these variants with BC risk in this population.
dc.identifier.doi10.21597/jist.1107271
dc.identifier.endpage1344
dc.identifier.issn2146-0574
dc.identifier.issn2536-4618
dc.identifier.issue3
dc.identifier.startpage1336
dc.identifier.trdizinid1123026
dc.identifier.urihttps://doi.org/10.21597/jist.1107271
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1123026
dc.identifier.urihttps://hdl.handle.net/11480/12185
dc.identifier.volume12
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofIğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241107
dc.subjectOnkoloji
dc.subjectGenetik ve Kalıtım
dc.subjectPolymorphism
dc.subjectBladder cancer
dc.subjectVNTR
dc.subjectIL-4
dc.subjectIL-1Ra
dc.titleAssociation of IL-4 and IL-1 Ra Gene Polymorphisms with the Risk of Bladder Cancer
dc.typeArticle

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