Crocin protects intestine tissue against carbon tetrachloride-mediated oxidative stress in rats

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dc.contributor.authorCosgun B.E.
dc.contributor.authorErdemli M.E.
dc.contributor.authorGul M.
dc.contributor.authorGul S.
dc.contributor.authorBag H.G.
dc.contributor.authorAksungur Z.
dc.contributor.authorAltinoz E.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2018
dc.departmentNiğde ÖHÜ
dc.description.abstractSaffron is used in traditional medicine for its hypolipidemic, anti-inflammatory and anti-carcinogenic properties as a natural remedy in treatment of diseases. The objective of the present study was to demonstrate the protective effect of crocin (one of the main ingredients of saffron) on carbon tetrachloride (CCl4) damage in intestinal mucosa. MDA, GSH, SOD, CAT, TAS and TOS levels were measured in experimental animal tissue samples and these were compared with histologic lesions induced by CCl4. CCl4 caused an increase in MDA, SOD, CAT and TOS levels and a significant decrease in GSH and TAS levels in rat intestinal tracts. After crocin treatment, serious improvements were observed in histological lesions and biochemical results in the intestinal tract. In conclusion, crocin inhibited the toxic effects induced by CCl4 in the intestine by its strong antioxidant properties. © 2018 Slovak Academy of Sciences. All rights reserved.
dc.description.sponsorshipAcknowledgement. The present study was sponsored by Karabük University scientific research fund. (KBU-BAP-15/2-YL-009).
dc.identifier.doi10.4149/gpb_2017057
dc.identifier.endpage409
dc.identifier.issn0231-5882
dc.identifier.issue4
dc.identifier.pmid30220678
dc.identifier.scopus2-s2.0-85052058122
dc.identifier.scopusqualityQ3
dc.identifier.startpage399
dc.identifier.urihttps://dx.doi.org/10.4149/gpb_2017057
dc.identifier.urihttps://hdl.handle.net/11480/1759
dc.identifier.volume37
dc.identifier.wosWOS:000442487900004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherSlovak Academy of Sciences
dc.relation.ispartofGeneral Physiology and Biophysics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCCl4
dc.subjectCrocin
dc.subjectIntestine
dc.subjectMDA
dc.subjectOxidative stress
dc.titleCrocin protects intestine tissue against carbon tetrachloride-mediated oxidative stress in rats
dc.typeArticle

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