Clinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units

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dc.authoridbilir, yeliz/0000-0003-2217-4741
dc.authoridakin sen, irem/0000-0002-5402-4636
dc.authoridATES AYHAN, Nazire/0000-0003-4121-1931
dc.authoridHanci, Pervin/0000-0002-7207-2041
dc.authoridMengi, Tugce/0000-0002-0639-0957
dc.authoridInci, Kamil/0000-0002-3815-4342
dc.authoridOZYILMAZ, EZGI/0000-0002-4535-705X
dc.contributor.authorGundogan, Kursat
dc.contributor.authorAkbudak, Ismail Hakki
dc.contributor.authorHanci, Pervin
dc.contributor.authorHalacli, Burcin
dc.contributor.authorTemel, Sahin
dc.contributor.authorGullu, Zuhal
dc.contributor.authorInci, Kamil
dc.date.accessioned2024-11-07T13:35:36Z
dc.date.available2024-11-07T13:35:36Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground: There are limited data on the long-term outcomes of COVID-19 from different parts of the world. Aims: To determine risk factors of 90-day mortality in critically ill patients in Turkish intensive care units (ICUs), with respiratory failure. Study design: Retrospective, observational cohort. Methods: Patients with laboratory-confirmed COVID-19 and who had been followed up in the ICUs with respiratory failure for more than 24 hours were included in the study. Their demographics, clinical characteristics, laboratory variables, treatment protocols, and survival data were recorded. Results: A total of 421 patients were included. The median age was 67 (IQR: 57-76) years, and 251 patients (59.6%) were men. The 90-day mortality rate was 55.1%. The factors independently associated with 90-day mortality were invasive mechanical ventilation (IMV) (HR 4.09 [95% CI: [2.20-7.63], P<.001), lactate level >2 mmol/L (2.78 [1.93-4.01], P<.001), age >= 60 years (2.45 [1.48-4.06)], P<.001), cardiac arrhythmia during ICU stay (2.01 [1.27-3.20], P=.003), vasopressor treatment (1.94 [1.32-2.84], P=.001), positive fluid balance of >= 600 mL/day (1.68 [1.21-2.34], P=.002), PaO2/FiO(2) ratio of <= 150 mmHg (1.66 [1.18-2.32], P=.003), and ECOG score >= 1 (1.42 [1.00-2.02], P=.050). Conclusion: Long-term mortality was high in critically ill patients with COVID-19 hospitalized in intensive care units in Turkey. Invasive mechanical ventilation, lactate level, age, cardiac arrhythmia, vasopressor therapy, positive fluid balance, severe hypoxemia and ECOG score were the independent risk factors for 90-day mortality.
dc.identifier.doi10.5152/balkanmedj.2021.21188
dc.identifier.endpage+
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue5
dc.identifier.pmid34558415
dc.identifier.scopus2-s2.0-85115428262
dc.identifier.scopusqualityQ3
dc.identifier.startpage296
dc.identifier.trdizinid481654
dc.identifier.urihttps://doi.org/10.5152/balkanmedj.2021.21188
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/481654
dc.identifier.urihttps://hdl.handle.net/11480/16576
dc.identifier.volume38
dc.identifier.wosWOS:000700853600007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofBalkan Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectNew-York-City
dc.subjectFluid Balance
dc.subjectCovid-19
dc.titleClinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units
dc.typeArticle

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