Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?

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dc.authoridKAPLAN, HUSEYIN/0000-0002-3292-0907
dc.authoridGunturk, Inayet/0000-0002-8299-1359
dc.contributor.authorKaplan, Huseyin
dc.contributor.authorCalis, Mustafa
dc.contributor.authorYazici, Cevat
dc.contributor.authorGunturk, Inayet
dc.contributor.authorCuce, Isa
dc.contributor.authorSenel, Abdurrahman Soner
dc.date.accessioned2024-11-07T13:32:05Z
dc.date.available2024-11-07T13:32:05Z
dc.date.issued2023
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractOBJECTIVE: Follistatin-like protein 1 (FSTL-1) and follistatin-like protein 3 (FSTL-3) are glycoproteins whose associations with inflammatory cytokines were reported in previous studies. However, it is not yet known whether they have an effect on the pathogenesis of familial Mediterranean fever (FMF). We aimed to detect the FSTL-1 and FSTL-3 levels and to determine their relationship to the attack status and mutation types in patients with FMF. METHODS: Fifty-six FMF patients and 22 healthy controls (HCs) were included in the study. Serum FSTL-1 and FSTL-3 levels were measured with the enzyme-linked immunosorbent assay method from collected serum samples. In addition, the MEditerranean FeVer (MEFV) gene mutation types of the patients were noted. RESULTS: Serum FSTL-1 levels were significantly higher in FMF patients than in HCs (p=0.005). However, there was no significant difference in FSTL-1 levels between patients in the attack period (n=26) and in the attack-free period (n=30). FSTL-3 levels were similar between FMF patients and HCs or patients in the attack period and in the attack-free period. Furthermore, the MEFV mutation type and attack status had no significant effect on FSTL-1 and FSTL-3 levels (p>0.05). CONCLUSION: Our results suggest that FSTL-1 may be associated with the pathogenesis of FMF, rather than FSTL-3. However, neither serum FSTL-1 nor FSTL-3 seems to be good markers to reflect inflammatory activity.
dc.description.sponsorshipcoordination unit of the Erciyes University Scientific Research Projects [TTU-2017-7499]
dc.description.sponsorship& nbsp;This study was supported by the coordination unit of the Erciyes University Scientific Research Projects (project no. TTU-2017-7499).
dc.identifier.doi10.14744/nci.2022.54189
dc.identifier.endpage313
dc.identifier.issn2148-4902
dc.identifier.issn2536-4553
dc.identifier.issue3
dc.identifier.pmid37435280
dc.identifier.scopus2-s2.0-85164672335
dc.identifier.scopusqualityN/A
dc.identifier.startpage306
dc.identifier.trdizinid1189854
dc.identifier.urihttps://doi.org/10.14744/nci.2022.54189
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1189854
dc.identifier.urihttps://hdl.handle.net/11480/15214
dc.identifier.volume10
dc.identifier.wosWOS:001041293500004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKare Publ
dc.relation.ispartofNorthern Clinics of Istanbul
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectFamilial Mediterranean fever
dc.subjectfollistatin-like protein 1
dc.subjectfollistatin-like protein 3
dc.subjectinflammation
dc.subjectinterleukin-1 beta
dc.titleAre follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?
dc.typeArticle

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