The effect of intradermal administration of inactive platelet-rich plasma on flap viability in rats

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dc.contributor.authorOrhan E.
dc.contributor.authorUysal A.Ç.
dc.contributor.authorBaşer E.
dc.contributor.authorKeskin D.
dc.contributor.authorDemiroğlu-Yakut Ç.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2017
dc.departmentNiğde ÖHÜ
dc.description.abstractPurpose: To evaluate the effect of inactive form of platelet rich plasma (PRP) on the flap viability. Methods: Thirty six rats were used. Rats were divided into six groups then 9x3 cm random pattern skin flaps were elevated from dorsum of all rats. For precluding vascularization from the base, a silicone layer was placed under the flap in groups 2(only flap+silicone), 4(saline+silicone) and 6(PRP+silicone). In groups 1(only flap), 2(only flap+silicone) nothing was done except flap surgery. In groups 3(saline) and 4(saline+silicone), saline was applied intradermally , in groups 5(PRP) and 6(PRP+silicone), inactive form of PRP which obtained from different 16 rats was applied intradermally, into certain points of flaps immediately after surgery. After 7 days flap necrosis ratio was measured in all groups. Results: Mean necrosis rate in group 5(PRP) (16.05%) was statistically significantly lower than group 1(only flap) (31,93%) and group 3(saline) (30,43%) (p<0.001). Mean necrosis rate in group 6(PRP+silicone) (36.37%) was statistically significantly lower than group 2(only flap+silicone) (47.93%) and group 4(saline+silicone) (45.65%) (p<0.001). Conclusion: Intradermal inactive platelet rich plasma administration decreases flap necrosis so for skin application. © 2017, Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia. All rights reserved.
dc.identifier.doi10.1590/s0102-865020170040000003
dc.identifier.endpage286
dc.identifier.issn0102-8650
dc.identifier.issue4
dc.identifier.pmid28538802
dc.identifier.startpage280
dc.identifier.urihttps://dx.doi.org/10.1590/s0102-865020170040000003
dc.identifier.urihttps://hdl.handle.net/11480/1812
dc.identifier.volume32
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherSociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPlatelet-Rich plasma
dc.subjectRats
dc.subjectSkin
dc.subjectSurgical flaps
dc.titleThe effect of intradermal administration of inactive platelet-rich plasma on flap viability in rats
dc.typeArticle

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