Decreased butyrylcholinesterase and oxytocin levels versus increased dopamine levels in advanced Alzheimer’s patients

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dc.contributor.authorAyan, Durmus
dc.contributor.authorÖzmen, Esma
dc.contributor.authorErşan, Serpil
dc.contributor.authorSari, İsmail
dc.contributor.authorErşan, Etem Erdal
dc.contributor.authorSöylemez, Sibel
dc.date.accessioned2024-11-07T13:19:28Z
dc.date.available2024-11-07T13:19:28Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAim: In this study, it was aimed to examine the serum levels of dopamine, oxytocin, and butyrylcholinesterase (BchE) enzyme activity in advanced Alzheimer’s disease (AD). Materials and Methods: For our preliminary study, a total of 40 participants were included in the study. 20 of the participants consisted of patients and the other 20 made up the control group. In the serum samples of the patient and control group, the lev- els of dopamine and oxytocin were measured by Enzyme-Linked Immuno Sorbent As- say (ELISA) method, while the BchE activity was measured by the spectrophotometric method. Results: We found that serum BchE and oxytocin levels in the AD group were sta- tistically lower than the controls (p<0.01, p=0.027), whereas serum dopamine levels in the AD group were statistically higher than the control group (p=0.02). Furthermore, we analyzed that there was no significant correlation between the measured parameters (p>0.05). Conclusion: Our results indicate that the decrease in BchE activity and oxytocin levels and the increase in dopamine levels may have a relationship with the progression of the disease in the AD group. However, we believe that studies are needed with larger numbers of patients with different levels of AD.
dc.identifier.doi10.5455/annalsmedres.2022.03.081
dc.identifier.endpage868
dc.identifier.issn2636-7688
dc.identifier.issue8
dc.identifier.startpage864
dc.identifier.trdizinid1126826
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2022.03.081
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1126826
dc.identifier.urihttps://hdl.handle.net/11480/13152
dc.identifier.volume29
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofAnnals of Medical Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241107
dc.subjectPatoloji
dc.subjectNörolojik Bilimler
dc.titleDecreased butyrylcholinesterase and oxytocin levels versus increased dopamine levels in advanced Alzheimer’s patients
dc.typeArticle

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