Expression levels of BAP1, OGT, and YY1 genes in patients with eyelid tumors
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Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Walter De Gruyter Gmbh
Access Rights
info:eu-repo/semantics/openAccess
Abstract
Objectives The aim of this study was to investigate BAP1, OGT and YY1 genes and protein levels in 12 samples (8 males, 4 females) of eyelid tumor tissue with basal cell carcinoma (BCC) and 12 normal control subjects (8 males, 4 females). Methods The expression levels of these genes were determined with RT-PCR and the protein levels and expression using ELISA and IHC methods, respectively. Results In RT-PCR analysis, statistically significant upregulated expression was determined of 1.84-fold of BAP1, 2.85-fold of OGT and 3.06-fold of YY1 genes (p < 0.05). In the patient group, compared to the control group, there was a similar statistically significant strong correlation between the proteins (BAP1 and YY1; r = 0.850, BAP1 and OGT; r = 0.811, OGT and YY1; r = 0.755) (p < 0.05). In the ELISA and IHC analysis methods, a significant increase in BAP1 and YY1 protein expression levels was observed compared to the control group (p < 0.05). Conclusions The study results demonstrated that BAP1 and YY1 genes and protein levels were upregulated in eyelid tumor tissue with BCC.
Description
Keywords
BAP1, basal cell carcinoma, expression, eyelid, OGT, tumor, YY1
Journal or Series
Turkish Journal of Biochemistry-Turk Biyokimya Dergisi
WoS Q Value
Q4
Scopus Q Value
Q4
Volume
46
Issue
6
