Expression levels of BAP1, OGT, and YY1 genes in patients with eyelid tumors

Küçük Resim Yok

Tarih

2021

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Walter De Gruyter Gmbh

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Objectives The aim of this study was to investigate BAP1, OGT and YY1 genes and protein levels in 12 samples (8 males, 4 females) of eyelid tumor tissue with basal cell carcinoma (BCC) and 12 normal control subjects (8 males, 4 females). Methods The expression levels of these genes were determined with RT-PCR and the protein levels and expression using ELISA and IHC methods, respectively. Results In RT-PCR analysis, statistically significant upregulated expression was determined of 1.84-fold of BAP1, 2.85-fold of OGT and 3.06-fold of YY1 genes (p < 0.05). In the patient group, compared to the control group, there was a similar statistically significant strong correlation between the proteins (BAP1 and YY1; r = 0.850, BAP1 and OGT; r = 0.811, OGT and YY1; r = 0.755) (p < 0.05). In the ELISA and IHC analysis methods, a significant increase in BAP1 and YY1 protein expression levels was observed compared to the control group (p < 0.05). Conclusions The study results demonstrated that BAP1 and YY1 genes and protein levels were upregulated in eyelid tumor tissue with BCC.

Açıklama

Anahtar Kelimeler

BAP1, basal cell carcinoma, expression, eyelid, OGT, tumor, YY1

Kaynak

Turkish Journal of Biochemistry-Turk Biyokimya Dergisi

WoS Q Değeri

Q4

Scopus Q Değeri

Q4

Cilt

46

Sayı

6

Künye