Expression levels of BAP1, OGT, and YY1 genes in patients with eyelid tumors

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dc.authoridErdogan, Haydar/0000-0002-9337-6968
dc.authoridSilig, Yavuz/0000-0002-0562-7457
dc.authoridTAS, Ayca/0000-0002-7132-1325
dc.contributor.authorTas, Ayca
dc.contributor.authorGumus, Erkan
dc.contributor.authorOzmen, Esma
dc.contributor.authorErdogan, Haydar
dc.contributor.authorSilig, Yavuz
dc.date.accessioned2024-11-07T13:34:52Z
dc.date.available2024-11-07T13:34:52Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjectives The aim of this study was to investigate BAP1, OGT and YY1 genes and protein levels in 12 samples (8 males, 4 females) of eyelid tumor tissue with basal cell carcinoma (BCC) and 12 normal control subjects (8 males, 4 females). Methods The expression levels of these genes were determined with RT-PCR and the protein levels and expression using ELISA and IHC methods, respectively. Results In RT-PCR analysis, statistically significant upregulated expression was determined of 1.84-fold of BAP1, 2.85-fold of OGT and 3.06-fold of YY1 genes (p < 0.05). In the patient group, compared to the control group, there was a similar statistically significant strong correlation between the proteins (BAP1 and YY1; r = 0.850, BAP1 and OGT; r = 0.811, OGT and YY1; r = 0.755) (p < 0.05). In the ELISA and IHC analysis methods, a significant increase in BAP1 and YY1 protein expression levels was observed compared to the control group (p < 0.05). Conclusions The study results demonstrated that BAP1 and YY1 genes and protein levels were upregulated in eyelid tumor tissue with BCC.
dc.description.sponsorshipSivas Cumhuriyet University [CUBAP T-687]
dc.description.sponsorshipThis research was supported by Sivas Cumhuriyet University via research grants provided to the project CUBAP T-687.
dc.identifier.doi10.1515/tjb-2021-0160
dc.identifier.endpage719
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85123446713
dc.identifier.scopusqualityQ4
dc.identifier.startpage709
dc.identifier.urihttps://doi.org/10.1515/tjb-2021-0160
dc.identifier.urihttps://hdl.handle.net/11480/16220
dc.identifier.volume46
dc.identifier.wosWOS:000734474200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectBAP1
dc.subjectbasal cell carcinoma
dc.subjectexpression
dc.subjecteyelid
dc.subjectOGT
dc.subjecttumor
dc.subjectYY1
dc.titleExpression levels of BAP1, OGT, and YY1 genes in patients with eyelid tumors
dc.title.alternativeGöz Kapağı Tümörlü Hastalarda BAP1, OGT ve YY1 Genlerinin İfade Düzeyleri
dc.typeArticle

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