CRISPR/Cas-mediated plant genome editing outstanding challenges a decade after implementation

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dc.authoridBruegmann, Tobias/0000-0001-9823-5630
dc.authoridBoniecka, Justyna/0000-0002-1753-9892
dc.authoridEeckhaut, Tom/0000-0001-5473-0314
dc.authoridNicolia, Alessandro/0000-0002-5420-5218
dc.authoridNowakowska, Justyna/0000-0001-5863-053X
dc.authoridCardi, Teodoro/0000-0001-9418-8849
dc.authoridBull, Simon E./0000-0003-0506-6984
dc.contributor.authorCardi, Teodoro
dc.contributor.authorMurovec, Jana
dc.contributor.authorBakhsh, Allah
dc.contributor.authorBoniecka, Justyna
dc.contributor.authorBruegmann, Tobias
dc.contributor.authorBull, Simon E.
dc.contributor.authorEeckhaut, Tom
dc.date.accessioned2024-11-07T13:35:36Z
dc.date.available2024-11-07T13:35:36Z
dc.date.issued2023
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThe discovery of the CRISPR/Cas genome-editing system has revolutionized our understanding of the plant genome. CRISPR/Cas has been used for over a decade to modify plant genomes for the study of specific genes and biosynthetic pathways as well as to speed up breeding in many plant species, including both model and non-model crops. Although the CRISPR/Cas system is very efficient for genome editing, many bottlenecks and challenges slow down further improvement and applications. In this review we discuss the challenges that can occur during tissue culture, transformation, regeneration, and mutant detection. We also review the opportunities provided by new CRISPR platforms and specific applications related to gene regulation, abiotic and biotic stress response improvement, and de novo domestication of plants.
dc.description.sponsorshipCOST (European Cooper- ation in Science and Technology) [CA18111]
dc.description.sponsorshipAcknowledgments This article/publication is based upon work from COST Action PlantEd (CA18111) , supported by COST (European Cooper- ation in Science and Technology) ( www.cost.eu) . The authors thank Gaetano Guarino for help with the artwork and Miriam Levenson for text editing of the manuscript.
dc.identifier.doi10.1016/j.tplants.2023.05.012
dc.identifier.endpage1165
dc.identifier.issn1360-1385
dc.identifier.issn1878-4372
dc.identifier.issue10
dc.identifier.pmid37331842
dc.identifier.scopus2-s2.0-85162853805
dc.identifier.scopusqualityQ1
dc.identifier.startpage1144
dc.identifier.urihttps://doi.org/10.1016/j.tplants.2023.05.012
dc.identifier.urihttps://hdl.handle.net/11480/16571
dc.identifier.volume28
dc.identifier.wosWOS:001077938900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCell Press
dc.relation.ispartofTrends in Plant Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectQuantitative Trait Variation
dc.subjectDe-Novo Domestication
dc.subjectFunctional-Analysis
dc.subjectCrop
dc.subjectTool
dc.subjectMutagenesis
dc.subjectExpression
dc.subjectMaize
dc.subjectOverexpression
dc.subjectImprovement
dc.titleCRISPR/Cas-mediated plant genome editing outstanding challenges a decade after implementation
dc.typeReview Article

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