EVALUATION OF AMINO ACID PROFILE IN SERUM OF PATIENTS WITH COVID-19 FOR PROVIDING A NEW TREATMENT STRATEGY
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Soc Medical Biochemists Serbia
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
BackgroundAmino acids have an important role in metabolism and may affect COVID-19-related outcomes. In our study, the amino acid serum level of hospitalized COVID19 patients was evaluated to determine a new treatment strategy.MethodsThe amino acid profile covering 43 amino acids in 68 subjects, comprising 30 (14 men and 16 women) controls and 38 (16 men and 22 women) COVID-19 patients, were examined. The amino acid profiles of the participants were screened by LC-MS/MS.ResultsCompared with the control group, serum levels of 27 amino acids increased in the patient group. Alpha-aminopimelic acid, sarcosine, and hydroxyproline amino acids were considerably higher in the control group than in the patient group (p<0.0001). There was no notable difference among control group and the case group for 13 amino acids (p >= 0.05). A significant positive correlation was seen among the control and the patient groups in the mean amino acid values (r=0.937; p<0.0001).ConclusionsThese results postulated a clear picture on the serum levels of amino acid in the COVID-19 patients. Serum amino acids measured in hospitalized COVID-19 patients can explain the patient's metabolic status during the disease.
Açıklama
Anahtar Kelimeler
amino acid, Covid-19, Sars-CoV-2, treatment strategy
Kaynak
Journal of Medical Biochemistry
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
41
Sayı
4
