EVALUATION OF AMINO ACID PROFILE IN SERUM OF PATIENTS WITH COVID-19 FOR PROVIDING A NEW TREATMENT STRATEGY

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dc.authoridBozok, Taylan/0000-0002-7094-4838
dc.authoridIbrahim, Bashar/0000-0001-7773-0122
dc.contributor.authorOzturkl, Ali
dc.contributor.authorBayraktar, Nihayet
dc.contributor.authorBayraktar, Mustafa
dc.contributor.authorIbrahim, Bashar
dc.contributor.authorBozok, Taylan
dc.contributor.authorCeylan, Mehmet Resat
dc.date.accessioned2024-11-07T13:35:00Z
dc.date.available2024-11-07T13:35:00Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackgroundAmino acids have an important role in metabolism and may affect COVID-19-related outcomes. In our study, the amino acid serum level of hospitalized COVID19 patients was evaluated to determine a new treatment strategy.MethodsThe amino acid profile covering 43 amino acids in 68 subjects, comprising 30 (14 men and 16 women) controls and 38 (16 men and 22 women) COVID-19 patients, were examined. The amino acid profiles of the participants were screened by LC-MS/MS.ResultsCompared with the control group, serum levels of 27 amino acids increased in the patient group. Alpha-aminopimelic acid, sarcosine, and hydroxyproline amino acids were considerably higher in the control group than in the patient group (p<0.0001). There was no notable difference among control group and the case group for 13 amino acids (p >= 0.05). A significant positive correlation was seen among the control and the patient groups in the mean amino acid values (r=0.937; p<0.0001).ConclusionsThese results postulated a clear picture on the serum levels of amino acid in the COVID-19 patients. Serum amino acids measured in hospitalized COVID-19 patients can explain the patient's metabolic status during the disease.
dc.identifier.doi10.5937/jomb0-37514
dc.identifier.endpage533
dc.identifier.issn1452-8258
dc.identifier.issn1452-8266
dc.identifier.issue4
dc.identifier.pmid36381071
dc.identifier.scopus2-s2.0-85141321901
dc.identifier.scopusqualityQ3
dc.identifier.startpage526
dc.identifier.urihttps://doi.org/10.5937/jomb0-37514
dc.identifier.urihttps://hdl.handle.net/11480/16270
dc.identifier.volume41
dc.identifier.wosWOS:000954576000013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSoc Medical Biochemists Serbia
dc.relation.ispartofJournal of Medical Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectamino acid
dc.subjectCovid-19
dc.subjectSars-CoV-2
dc.subjecttreatment strategy
dc.titleEVALUATION OF AMINO ACID PROFILE IN SERUM OF PATIENTS WITH COVID-19 FOR PROVIDING A NEW TREATMENT STRATEGY
dc.title.alternativePROCENA AMINOKISELINSKOG PROFILA U SERUMU PACIJENATA SA COVID-19 ZA OBEZBE\IVANJE NOVE STRATEGIJE LE^ENJA
dc.typeArticle

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