The effects of N-acetylcysteine on cisplatin induced cardiotoxicity

Basit Öğe Kaydı
dc.contributor.authorGunturk E.E.
dc.contributor.authorYucel B.
dc.contributor.authorGunturk I.
dc.contributor.authorYazici C.
dc.contributor.authorYay A.
dc.contributor.authorKose K.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2019
dc.departmentNiğde ÖHÜ
dc.description.abstractOBJECTIVES: Recent studies reported that oxidative stress is an important mechanism that contributes to cisplatin induced cardiotoxicity. In the present study, the effects of N-acetylcysteine (NAC), which is an antioxidant, on cisplatin induced cardiotoxicity were investigated in a rat model. METHODS: Thirty two rats were separated into 4 equal groups: Control, NAC-250, CP (cisplatin), CP+NAC. Rats in the experimental groups were treated with a single dose of cisplatin intraperitoneally (ip) (10 mg/kg) and NAC (ip, 250 mg/kg) for 3 consecutive days. At the end of the experiment, cardiotoxicity was determined from plasma CK-MB, LDH, cTnI and cardiac myosin light chain-1 (CMLC-1) levels. In the tissue samples, total oxidant capacity (TOC), total antioxidant capacity (TAC), lipid hydroperoxide (ROOH) and thiol levels were measured. The hearts were also analyzed histopathologically. RESULTS: It was determined that cisplatin increased the tissue TOC, ROOH levels and decreased TAC and thiol levels. NAC administration after cisplatin treatment was observed to have ameliorated histological and functional changes in heart. CONCLUSIONS: In conclusion, the results of this experimental study suggested that oxidative stress had a serious effect on cisplatin cardiotoxicity, and NAC could be used as a therapeutic agent in addition to standard cisplatin treatment protocols. © 2019, AEPress s.r.o.
dc.description.sponsorshipErciyes Üniversitesi
dc.description.sponsorshipThis study was supported by the Research Fund of Erciyes University (Grant No. TTU-2015-6134).
dc.identifier.doi10.4149/BLL_2019_068
dc.identifier.endpage428
dc.identifier.issn0006-9248
dc.identifier.issue6
dc.identifier.pmid31223022
dc.identifier.scopus2-s2.0-85068072103
dc.identifier.scopusqualityQ3
dc.identifier.startpage423
dc.identifier.urihttps://dx.doi.org/10.4149/BLL_2019_068
dc.identifier.urihttps://hdl.handle.net/11480/1547
dc.identifier.volume120
dc.identifier.wosWOS:000472479100004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherComenius University
dc.relation.ispartofBratislava Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCardiotoxicity
dc.subjectCisplatin
dc.subjectN-acetylcysteine
dc.subjectOxidative stress
dc.subjectRats
dc.titleThe effects of N-acetylcysteine on cisplatin induced cardiotoxicity
dc.typeArticle

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu