The Effect of Triclosan on In vitro Embryonic Development in Rat

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dc.contributor.authorCayan, Dicle
dc.contributor.authorUnur, Erdogan
dc.contributor.authorNisari, Mehtap
dc.contributor.authorPatat, Dilara
dc.contributor.authorDagli, Ertugrul
dc.contributor.authorAkalin, Hilal
dc.date.accessioned2024-11-07T13:23:54Z
dc.date.available2024-11-07T13:23:54Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description1st International Mediterranean Anatomy Congress (IMAC) -- SEP 06-09, 2018 -- Konya, TURKEY
dc.description.abstractTriclosan (TCS) is a broad spectrum antimicrobial agent showing its effect by deactivating the fatty acid synthesis of bacteria. The aim of this study was to investigate the effects of TCS on in vitro embryonic development in rats and to determine the levels of caspases 2, 7, 8, and 9 inducing cells to apoptosis through gene expression. According to the TCS dose added to the culture whole rat serum, 3 experimental groups and a control group were formed with each including 10 embryos. After 48 h culturing period, embryos were subjected to morphological scoring for developmental evaluation. The levels of caspases 2, 7, 8, and 9 were measured by performing gene expression on 40 embryos. Significant decreases were obtained in all parameters of morphological scoring in the experimental groups as the dose of TCS increased. While the caspase-2 level showed a significant decrease among the groups and was inversely proportional to the level of TCS, the caspase-9 level showed a significant increase among the groups and was directly proportional to the level of TCS. In conclusion, TCS was determined to cause apoptosis in the cells via the intrinsic pathway during pregnancy period and lead to embryonic growth retardation, which increased with increased dose of TCS.
dc.identifier.doi10.9775/kvfd.2020.23873
dc.identifier.endpage602
dc.identifier.issn1300-6045
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85089661447
dc.identifier.scopusqualityQ3
dc.identifier.startpage595
dc.identifier.trdizinid364653
dc.identifier.urihttps://doi.org/10.9775/kvfd.2020.23873
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/364653
dc.identifier.urihttps://hdl.handle.net/11480/13783
dc.identifier.volume26
dc.identifier.wosWOS:000562133000003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisi
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectTriclosan
dc.subjectRat embryo culture
dc.subjectApoptosis
dc.subjectGene expression
dc.subjectCaspase
dc.titleThe Effect of Triclosan on In vitro Embryonic Development in Rat
dc.title.alternativeTriklosanın in vitro embriyonik rat gelişimi üzerine etkisi
dc.typeConference Object

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