Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy?

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dc.contributor.authorOzer, Hakan
dc.contributor.authorAydoğan, Kader Zeybek
dc.contributor.authorOzturk, Yasin
dc.contributor.authorYonet, Fethi
dc.contributor.authorBaloglu, Ismail
dc.date.accessioned2024-11-07T13:19:27Z
dc.date.available2024-11-07T13:19:27Z
dc.date.issued2023
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground and Aim: Diabetic nephropathy is the most common cause of end-stage renal disease and albuminuria is the earliest manifestation of diabetic nephropathy.Oxidative stress and inflammation caused by advanced glyco-oxidation end products contribute to micro and macrovascular complications of diabetes. Monocyte to high-density lipoprotein (HDL) cholesterol ratio (MHR) is an essential indicator of inflammation and oxidative stress. In this study, we aimed to reveal the relationship between diabetes regulation and complications and MHR. Material and Method: A total of 182 subjects, including 152 patients with diabetes mellitus (DM) and 30 healthy controls, were included in this study. All data of the subjects were scanned retrospectively. The DM group was divided into two groups nephropathy (n=68) and non-nephropathy (n=84), with a limit of 30 mg/day for albuminuria. MHR was calculated by dividing the monocyte count by the HDL cholesterol count. Results: When patients with DM were divided into nephropathy and non-nephropathy, patients with nephropathy had higher MHR levels than the other group. We showed that MHR correlated with albuminuria, creatinine, and HbA1c in patients with diabetic nephropathy. In addition, in the regression analysis, albuminuria and MHR were predictors of DN, while MHR, age, and creatinine were found to be independent predictors of albuminuria. Conclusion: MHR, which is an easily calculated marker with simple laboratory tests, which is frequently requested in routine practice in the follow-up of diabetes patients, can help predict the regulation of diabetes and its kidney complications.
dc.identifier.doi10.54005/geneltip.1206894
dc.identifier.endpage389
dc.identifier.issn2602-3741
dc.identifier.issue4
dc.identifier.startpage384
dc.identifier.trdizinid1197177
dc.identifier.urihttps://doi.org/10.54005/geneltip.1206894
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1197177
dc.identifier.urihttps://hdl.handle.net/11480/13125
dc.identifier.volume33
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofGenel Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241107
dc.subjectTıbbi İnformatik
dc.subjectKadın Hastalıkları ve Doğum
dc.subjectGenel ve Dahili Tıp
dc.subjectPatoloji
dc.subjectKimya
dc.subjectUygulamalı
dc.subjectKimya
dc.subjectTıbbi
dc.subjectInflamasyon
dc.subjectAlbüminüri
dc.subjectinflammation
dc.subjectdiabetic nephropathy
dc.subjectAlbuminuria
dc.subjectmonocyte-hdl cholesterol ratio
dc.subjectdiyabetik nefropati
dc.subjectmonosit-HDL kolesterol oranı
dc.titleMonocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy?
dc.typeArticle

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