Investigation of the protective and therapeutic effects of ?-aminoisobutyric acid (BAIBA) and Thymoquinone in the diabetic nephropathy
Küçük Resim Yok
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ms-Editions
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, against streptozotocin (STZ) induced diapetic nephropathy (DN); it is aimed to investigate the use of thymoquinone (TQ) and beta-aminoisobutyric acid (BAIBA) and to compare the effects of these agents. With random selection of 35 male rats, five groups (seven rats in each group) were constituted as follows: Control, STZ, STZ + TQ, STZ + BAIBA, STZ + TQ + BAIBA. In the STZ group; body weight, glutathione (GSH) and insulin levels decreased, relative kidney v.:iglu, malondialdehyde (MDA), glucose, blood urea nitrogen (BUN) and creatinine (Cr) levels were increased. Also, in kidney tissue; histopathological changes (such as thickening of the capsular, glomerular and tubular basement membranes, increased mesangial matrix amount, increased cytoplasmic vacuolization in some of the tubular epithelial cells, increased tumor necrosis factor-alpha (TNF-alpha) expression, and inflammatory cell infiltrations in interstitial tissue) were detected. It was observed that these changes occurring after diabetes mellitus (DM) reversed significantly in TQ, BAIBA and TQ + BAIBA groups.
Açıklama
Anahtar Kelimeler
beta-aminoisobutyric acid, Diabetic nephropathy, Rat, Streptozotocin, Thymoquinone
Kaynak
Boletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
20
Sayı
3
