Investigation of the protective and therapeutic effects of ?-aminoisobutyric acid (BAIBA) and Thymoquinone in the diabetic nephropathy

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dc.authoridAKTAS, IBRAHIM/0000-0002-0956-8204
dc.authoridGUR, FATIH MEHMET/0000-0001-7748-3272
dc.contributor.authorAktas, Ibrahim
dc.contributor.authorGur, Fatih Mehmet
dc.date.accessioned2024-11-07T13:25:24Z
dc.date.available2024-11-07T13:25:24Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractIn this study, against streptozotocin (STZ) induced diapetic nephropathy (DN); it is aimed to investigate the use of thymoquinone (TQ) and beta-aminoisobutyric acid (BAIBA) and to compare the effects of these agents. With random selection of 35 male rats, five groups (seven rats in each group) were constituted as follows: Control, STZ, STZ + TQ, STZ + BAIBA, STZ + TQ + BAIBA. In the STZ group; body weight, glutathione (GSH) and insulin levels decreased, relative kidney v.:iglu, malondialdehyde (MDA), glucose, blood urea nitrogen (BUN) and creatinine (Cr) levels were increased. Also, in kidney tissue; histopathological changes (such as thickening of the capsular, glomerular and tubular basement membranes, increased mesangial matrix amount, increased cytoplasmic vacuolization in some of the tubular epithelial cells, increased tumor necrosis factor-alpha (TNF-alpha) expression, and inflammatory cell infiltrations in interstitial tissue) were detected. It was observed that these changes occurring after diabetes mellitus (DM) reversed significantly in TQ, BAIBA and TQ + BAIBA groups.
dc.description.sponsorshipAdiyaman University Research Foundation [SHMYOMAP/2018-0001]
dc.description.sponsorshipThis study was supported by a grant from Adiyaman University Research Foundation (Project SHMYOMAP/2018-0001).
dc.identifier.doi10.37360/blacpma.21.20.3.22
dc.identifier.endpage314
dc.identifier.issn0717-7917
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85102963172
dc.identifier.scopusqualityQ3
dc.identifier.startpage303
dc.identifier.urihttps://doi.org/10.37360/blacpma.21.20.3.22
dc.identifier.urihttps://hdl.handle.net/11480/14669
dc.identifier.volume20
dc.identifier.wosWOS:000626114800006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMs-Editions
dc.relation.ispartofBoletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectbeta-aminoisobutyric acid
dc.subjectDiabetic nephropathy
dc.subjectRat
dc.subjectStreptozotocin
dc.subjectThymoquinone
dc.titleInvestigation of the protective and therapeutic effects of ?-aminoisobutyric acid (BAIBA) and Thymoquinone in the diabetic nephropathy
dc.title.alternativeInvestigación de los efectos protectores y terapéuticos del ácido ?-aminoisobutírico (Baiba) y la timoquinona en la nefropatía diabética
dc.typeArticle

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