Evaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism

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dc.authoridYAZICI, Cevat/0000-0003-0625-9542
dc.authoridSEYDEL, GONUL SEYDA/0000-0001-9317-0719
dc.authoridGunturk, Inayet/0000-0002-8299-1359
dc.contributor.authorDagli, Fatma
dc.contributor.authorGunturk, Inayet
dc.contributor.authorSeydel, Gonul Seyda
dc.contributor.authorYazici, Cevat
dc.date.accessioned2024-11-07T13:32:44Z
dc.date.available2024-11-07T13:32:44Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractPurpose: This study aims to investigate the effects of experimental hyperthyroidism and carnosine which is known to have antioxidant properties on physical and vital findings in rats, and to determine the relationship between these parameters and free T3 (FT3) levels. Materials and Methods: Rats were analyzed in 7 groups (each containing 12 animals); control (CONT), hyperthyroidism-1 (T:10-day L-thyroxine (L-T4) administration), hyperthyroidism-2 (T-T: 20-day L-T4 administration), Carnosine (10 day carnosine administration), Hyperthyroidism-1 + Carnosine (T-C), Hyperthyroidism-2 + Carnosine (T-TC), and Carnosine + Hyperthyroidism-1 (C-T). In order to create a hyperthyroidism model, L-thyroxine (L-T4) doses of 300 mu g/kg rat weight/day and carnosine doses of 300 mu g/kg rat weight/ day were intraperitoneally (ip) administered to the rats. Results: After 10 and 20 days of thyroxine administration, FT3 levels (T:3.64 +/- 0.51pg/mL, T-T: 4.06 +/- 0.91pg/mL) and body temperature (T:37.1 +/- 0.3oC, T-T: 37.6 +/- 0.3oC), significantly increased while body weight decreased (T:240.7 +/- 22.0g, T-T:263 +/- 0.28.7g). Carnosine administration only prevented the increase of FT3 levels, but had no effect on other parameters. Conclusion: The increased FT3 levels observed with LT4 administration were consistent with the physical and vital findings, but carnosine administration did not reflect the expected effects on the physical findings observed in the hyperthyroid condition.
dc.description.sponsorshipResearch Fund of Erciyes University [TSD-10-3080]
dc.description.sponsorshipThis study was supported by the Research Fund of Erciyes University (Grant No: TSD-10-3080)
dc.identifier.doi10.17826/cumj.1099652
dc.identifier.endpage1066
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue3
dc.identifier.startpage1059
dc.identifier.trdizinid1122169
dc.identifier.urihttps://doi.org/10.17826/cumj.1099652
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1122169
dc.identifier.urihttps://hdl.handle.net/11480/15565
dc.identifier.volume47
dc.identifier.wosWOS:000889635700015
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherCukurova Univ, Fac Medicine
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectHyperthyroidism
dc.subjectbody temperature
dc.subjectheart weight
dc.subjectbody weight
dc.subjectcarnosine
dc.titleEvaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism
dc.typeArticle

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