Protective effect of dexpanthenol against cisplatin-induced hepatotoxicity

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dc.contributor.authorBilgic Y.
dc.contributor.authorAkbulut S.
dc.contributor.authorAksungur Z.
dc.contributor.authorErdemli M.E.
dc.contributor.authorOzhan O.
dc.contributor.authorParlakpinar H.
dc.contributor.authorTurkoz Y.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2018
dc.departmentNiğde ÖHÜ
dc.description.abstractThe aim of the present study was to investigate the protective effect of dexpanthenol (Dexp) against cisplatin (Cis)-induced hepatotoxicity. Thirty-two Sprague Dawley rats were divided into four groups: Control group (n=8), Dexp group (n=8, 500 mg/kg/ip/daily single dose/3 days Dexp), Cis group (n=8, 7 mg/kg/ip/single dose Cis) and Cis+Dexp group (n=8, 500 mg/kg/ip/daily single dose/3 days Dexp +7 mg/kg/ip/single dose Cis). MDA, CAT, GSH, GSH-Px, TOS, TAS, OSI, Total Nitrit, IL-1ß, IL-6 and TNF-? levels were analyzed in liver tissue samples. After paraffinization of liver tissue samples, histopathological (congestion, loss of glycogen, number of Kupffer cells) and immunohistochemical (caspase-3 expression) parameters were assessed on the paraffinized liver sections. GSH, TAS, TOS, OSI, Tot Nit, L-Arginine, ADMA and SDMA levels were measured in the serum samples. Statistically significant differences were found between the groups in terms of all liver tissue biochemical parameters, with the exception of IL-1ß and TNF-? levels. GSH, CAT, GSH-Px, TAS and Tot Nit levels were significantly higher in the Cis+Dexp group compared to the Cis group, whereas MDA, TOS, OSI and IL-6 levels were higher in the Cis group. Similarly, serum GSH, TAS, Tot Nit levels were higher in the Cis+Dexp group whereas TOS, L-Arginine, ADMA and SDMA levels were higher in Cis group. There were statistically significant differences between Control and Cis groups in terms of congestion increase, increase of glycogen loss, increase of Kupffer cell number and increase of caspase-3 expression (P<0.001). There was a statistically significant difference between the Cis and the Cis+Dexp groups in terms of histopathologic parameters, with the exception of congestion (P<0.001). To conclude, histopathological, immunohistochemical, and biochemical results of this study demonstrated that Dexp has a protective effect against Cis-induced hepatotoxicity. © 2018, Spandidos Publications. All rights reserved.
dc.description.sponsorshipFirat University Scientific Research Projects Management Unit Firat University Scientific Research Projects Management Unit
dc.description.sponsorshipUniversity Faculty of Medicine Animal Research Ethics Committee (2016/A-36). It was funded by Inonu University Scientific Research Project Coordination Unit (Project no. 2016/179).
dc.description.sponsorshipThe present study was supported by the Inonu University Scientific Research Project Coordination Unit (grant no. 2016/179).
dc.identifier.doi10.3892/etm.2018.6683
dc.identifier.endpage4057
dc.identifier.issn1792-0981
dc.identifier.issue5
dc.identifier.pmid30402149
dc.identifier.scopus2-s2.0-85053855999
dc.identifier.scopusqualityN/A
dc.identifier.startpage4049
dc.identifier.urihttps://dx.doi.org/10.3892/etm.2018.6683
dc.identifier.urihttps://hdl.handle.net/11480/1592
dc.identifier.volume16
dc.identifier.wosWOS:000448431900040
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherSpandidos Publications
dc.relation.ispartofExperimental and Therapeutic Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntioxidant potential
dc.subjectCisplatin
dc.subjectDexpanthenol
dc.subjectHepatotoxicity
dc.titleProtective effect of dexpanthenol against cisplatin-induced hepatotoxicity
dc.typeArticle

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