The effect of N-acetylcysteine on inflammation and oxidative stress in cisplatin-induced nephrotoxicity: a rat model

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dc.authoridYAZICI, Cevat/0000-0003-0625-9542
dc.authoridGunturk, Inayet/0000-0002-8299-1359
dc.contributor.authorGunturk, Inayet
dc.contributor.authorYazici, Cevat
dc.contributor.authorKose, Kader
dc.contributor.authorDagli, Fatma
dc.contributor.authorYucel, Bilal
dc.contributor.authorYay, Arzu
dc.date.accessioned2024-11-07T13:33:01Z
dc.date.available2024-11-07T13:33:01Z
dc.date.issued2019
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground/Aim: Cisplatin is a highly effective chemotherapeutic agent used in the treatment of solid organ cancers. Besides its chemotherapeutic effectiveness, cisplatin administration is associated with numerous side effects. Of those, the most clinically significant and common effect is nephrotoxicity. Recent studies reported that oxidative stress and inflammation are probably the most important mechanisms that contribute to the nephrotoxicity. N-acetylcysteine (NAC) is an antioxidant and antiinflammatory agent. In the present study, the effects of NAC on cisplatin-induced nephrotoxicity were investigated. Materials and methods: Rats were divided into four groups each including eight rats: CONT, NAC-250, CP, and CP+NAC. Rats in experimental groups were treated intraperitoneally (i.p.) with a single dose of cisplatin (10 mg/kg body weight) and i.p. with NAC (250 mg/kg body weight) for three consecutive days. Nephrotoxicity was determined by plasma BUN and creatinine levels. In tissue samples, myeloperoxidase (MPO), nuclear factor-kappa B (NF-kB), high mobility group box-1 (HMG B-1), total oxidant status (TOS), and total antioxidant status (TAS) levels were measured. Kidneys were analyzed histopathologically as well. Results: It was revealed that cisplatin was not effective on MPO, HMGB-1 and NF-kB levels but did increase TOS levels and decrease TAS levels in tissue samples. Interestingly, NAC elevated MPO and HMGB-1 levels significantly. Nevertheless, NAC ameliorated histological and functional changes in kidney tissues. Conclusion: It is suggested that inflammation has a limited effect on cisplatin nephrotoxicity in this experimental design, and, as reflected by decreased BUN and creatinine levels, NAC can be used as an additional therapeutic agent in standard cisplatin treatment protocols.
dc.description.sponsorshipResearch Fund of Erciyes University [TDK.2014-5056]
dc.description.sponsorshipThis study was supported by the Research Fund of Erciyes University (TDK.2014-5056).
dc.identifier.doi10.3906/sag-1903-225
dc.identifier.endpage1799
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6
dc.identifier.pmid31655538
dc.identifier.scopus2-s2.0-85076873852
dc.identifier.scopusqualityQ3
dc.identifier.startpage1789
dc.identifier.trdizinid536159
dc.identifier.urihttps://doi.org/10.3906/sag-1903-225
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/536159
dc.identifier.urihttps://hdl.handle.net/11480/15741
dc.identifier.volume49
dc.identifier.wosWOS:000504051300028
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectRats
dc.subjectcisplatin
dc.subjectoxidative stress
dc.subjectinflammation
dc.subjectN-acetylcysteine
dc.titleThe effect of N-acetylcysteine on inflammation and oxidative stress in cisplatin-induced nephrotoxicity: a rat model
dc.typeArticle

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