Protective effects of crocin on biochemistry and histopathology of experimental periodontitis in rats

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dc.contributor.authorKocaman G.
dc.contributor.authorAltinoz E.
dc.contributor.authorErdemli M.E.
dc.contributor.authorGul M.
dc.contributor.authorErdemli Z.
dc.contributor.authorGul S.
dc.contributor.authorBag H.G.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2019
dc.departmentNiğde ÖHÜ
dc.description.abstractWe investigated the effectiveness of crocin for preventing oxidative damage in experimentally produced periodontitis. We used three groups of 10 female Wistar rats divided into: control (C); experimental periodontitis (EP), experimental periodontitis + crocin (Cr-EP). Malondialdehyde (MDA), glutathione (GSH), total antioxidant status (TAS), total oxidant status (TOS) and superoxide dismutase (SOD) and catalase (CAT) enzyme activities were measured. We examined histopathology and inflammatory cell infiltration in gingiva and periodontal ligament. MDA and TOS levels, and SOD and CAT activities increased significantly in rats with induced periodontitis compared to the control group, while GSH and TAS levels were decreased significantly compared to the control group. Histopathologic examination revealed inflammatory cell infiltration in gingiva epithelium and subepithelial connective tissue in the EP group. Histological damage was reduced significantly after crocin treatment compared to the EP group. Crocin supplementation may help reduce oxidative damage to periodontal tissues. © 2019, © 2019 The Biological Stain Commission.
dc.identifier.doi10.1080/10520295.2019.1571229
dc.identifier.issn1052-0295
dc.identifier.pmid30982354
dc.identifier.scopus2-s2.0-85064495109
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1080/10520295.2019.1571229
dc.identifier.urihttps://hdl.handle.net/11480/1568
dc.identifier.wosWOS:000466679700001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherTaylor and Francis Ltd
dc.relation.ispartofBiotechnic and Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCrocin
dc.subjectoxidative stress
dc.subjectperiodontal disease
dc.subjectperiodontitis
dc.titleProtective effects of crocin on biochemistry and histopathology of experimental periodontitis in rats
dc.typeArticle

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