Protective effects of crocin on biochemistry and histopathology of experimental periodontitis in rats

Küçük Resim Yok

Tarih

2019

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Taylor and Francis Ltd

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

We investigated the effectiveness of crocin for preventing oxidative damage in experimentally produced periodontitis. We used three groups of 10 female Wistar rats divided into: control (C); experimental periodontitis (EP), experimental periodontitis + crocin (Cr-EP). Malondialdehyde (MDA), glutathione (GSH), total antioxidant status (TAS), total oxidant status (TOS) and superoxide dismutase (SOD) and catalase (CAT) enzyme activities were measured. We examined histopathology and inflammatory cell infiltration in gingiva and periodontal ligament. MDA and TOS levels, and SOD and CAT activities increased significantly in rats with induced periodontitis compared to the control group, while GSH and TAS levels were decreased significantly compared to the control group. Histopathologic examination revealed inflammatory cell infiltration in gingiva epithelium and subepithelial connective tissue in the EP group. Histological damage was reduced significantly after crocin treatment compared to the EP group. Crocin supplementation may help reduce oxidative damage to periodontal tissues. © 2019, © 2019 The Biological Stain Commission.

Açıklama

Anahtar Kelimeler

Crocin, oxidative stress, periodontal disease, periodontitis

Kaynak

Biotechnic and Histochemistry

WoS Q Değeri

Q4

Scopus Q Değeri

Q2

Cilt

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