Effects of Allium tuncelianum on hyperglycemia and oxidative stress in the kidney and liver tissues in rats with diabetes mellitus induced by streptozotocin

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dc.contributor.authorAtila, Gozde
dc.contributor.authorBilgili, Ali
dc.contributor.authorUslu, Hamit
dc.contributor.authorErdag, Dincer
dc.contributor.authorOzkan, Oktay
dc.date.accessioned2024-11-07T13:34:16Z
dc.date.available2024-11-07T13:34:16Z
dc.date.issued2019
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractIn this study, it was aimed to investigate the effects of Allium tuncelianum extract on hyperglycemia and oxidative stress in the kidney and liver tissues in rats with diabetes mellitus induced by streptozotocin. The rats were randomly divided into 4 groups with 10 animals in each group: Control group (C) was intraperitoneally (i.p.) treated with physiological saline solution, diabetic control (DC) group i.p. with a single dose of 50 mg/kg streptozotocin (STZ), diabetic + insulin (D+I) group i.p. with a single dose of 50 mg/kg STZ and subcutaneously (s.c.) with 2 IU insulin for 28 days (Levemir Flexpen), diabetic + Allium tuncelianum extract (D+AT) group i.p. with a single dose of 50 mg/kg STZ and orally with 250 mg/kg Allium tuncelianum extract for 28 days. The serum glycated hemoglobin (HbA1c), insulin levels and the kidney and liver thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), and catalase (CAT) activities were determined by using ELISA kits. Increased blood glucose levels (p<0.001), increased TBARS levels (p<0.001, p<0.01 respectively), and decreased SOD and CAT activities (p<0.001) in the kidney and liver tissue homogenates were determined in diabetic control group compared to control group. Allium tuncelianum extract had potent antioxidant activities in the diabetic rats, and demonstrated improvement effects by increasing insulin levels, decreasing glycated hemoglobin levels, and attenuating oxidative stress in the diabetic rats. This study suggests that Allium tuncelianum extract may have therapeutic potential for patients with diabetes.
dc.identifier.doi10.33988/auvfd.430457
dc.identifier.endpage190
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85077031486
dc.identifier.scopusqualityQ3
dc.identifier.startpage185
dc.identifier.trdizinid315225
dc.identifier.urihttps://doi.org/10.33988/auvfd.430457
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/315225
dc.identifier.urihttps://hdl.handle.net/11480/15879
dc.identifier.volume66
dc.identifier.wosWOS:000471803700010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAnkara Univ Press
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectAllium tuncelianum
dc.subjectantioxidant
dc.subjectdiabetes
dc.subjectoxidative stress
dc.subjectrat
dc.titleEffects of Allium tuncelianum on hyperglycemia and oxidative stress in the kidney and liver tissues in rats with diabetes mellitus induced by streptozotocin
dc.title.alternativeStreptozotosin ile diyabetes mellitus oluşturulan sıçanlarda Allium tuncelianum’un hiperglisemi ve böbrek ve karaciğer dokularında oksidatif stres üzerine etkileri
dc.typeArticle

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