Two Different Presentation of C3 Glomerulonephritis Treated with Eculizumab: Two Cases and Brief Overview

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dc.authoridOZER, Hakan/0000-0001-9174-0351
dc.contributor.authorOzturk, Yasin
dc.contributor.authorOzer, Hakan
dc.contributor.authorBaloglu, Ismail
dc.contributor.authorTurkmen, Kultigin
dc.date.accessioned2024-11-07T13:32:23Z
dc.date.available2024-11-07T13:32:23Z
dc.date.issued2023
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractC3 glomerulopathy is a newly defined glomerular disease dominated by C3 complement storage and uncertain C1, C4, and immunoglobin accumulations. Hereditary mutations associated with Complement Factor H (CFH) causing hyperactivation of the alternative complement pathway were identified. Most mutations associated with C3 glomerulopathy are associated with the N-terminal end. Whether mutations are pathogenic or not will direct diagnosis and treatment. We present 2 cases, one 61-year-old and one 24-year-old attending our clinic at different times with hematuria, proteinuria, edema, and kidney failure. Both patients had C3 glomerulopathy diagnosed based on the results of kidney biopsy and were treated with eculizumab. Both cases had CFH-associated mutations.
dc.identifier.doi10.5152/turkjnephrol.2023.21141125
dc.identifier.endpage89
dc.identifier.issn2667-4440
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85168823144
dc.identifier.scopusqualityQ4
dc.identifier.startpage86
dc.identifier.trdizinid1173115
dc.identifier.urihttps://doi.org/10.5152/turkjnephrol.2023.21141125
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1173115
dc.identifier.urihttps://hdl.handle.net/11480/15385
dc.identifier.volume32
dc.identifier.wosWOS:000925209300013
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAves
dc.relation.ispartofTurkish Journal of Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectClinical nephrology
dc.subjectC3 glomerulopathy
dc.subjectCFH
dc.subjecteculizumab
dc.subjectmutation
dc.subjectpathology
dc.titleTwo Different Presentation of C3 Glomerulonephritis Treated with Eculizumab: Two Cases and Brief Overview
dc.typeArticle

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