Investigation of CTLA-4 gene +49 A/G polymorphism in patients with bladder cancer

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dc.contributor.authorBudak Diler, Songül
dc.date.accessioned2024-11-07T10:39:48Z
dc.date.available2024-11-07T10:39:48Z
dc.date.issued2017
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjective: Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a member of the immunoglobulin superfamily. This stimulator molecule is expressed by active T cells. Recent studies have determined that dysfunction of CTLA-4 antigen leads to various diseases (Behçet's disease, diabetes, Graves' disease and systemic lupus erythematosus). It has also been suggested that there may be a relationship between the CTLA-4 gene and various cancers (breast cancer, osteosarcoma, and cervical cancer). In this study, It was investigated whether the CTLA-4 gene +49 A/G (rs231775) polymorphism could be assessed as a risk factor for bladder cancer patients. Material and Methods: This study included 69 patients with bladder cancer (62.07 ± 10.48 years) with similar age distribution and 149 healthy control (61.54 ± 14.43 years). Genotypes were determined by the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. Data was analysed using the Chi-square test and Hardy-Weinberg test. The Hardy-Weinberg equilibrium test was used to test the distributions of genotype frequency. Results: AA genotype was found in 41 (60%, in patients), 81 (55%, in control), AG genotype 23 (33%), 54 (36%) and GG genotype 5 (7%), 14 (9%) respectively in patients with bladder cancer and in healthy control groups. The frequency of GG genotype in patients was less than controls, but there was no statistically significant difference in the frequencies of GG genotype between patients and controls (P=0.52). Conclusions: These results indicated that genotype and allele frequencies of CTLA-4 gene +49 A/G polymorphism were not statistically significant different between bladder cancer patients and control groups. © 2017 by Türkiye Klinikleri.
dc.identifier.doi10.5336/medsci.2016-54052
dc.identifier.endpage20
dc.identifier.issn1300-0292
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85017435278
dc.identifier.scopusqualityQ4
dc.identifier.startpage16
dc.identifier.urihttps://doi.org/10.5336/medsci.2016-54052
dc.identifier.urihttps://hdl.handle.net/11480/11216
dc.identifier.volume37
dc.indekslendigikaynakScopus
dc.language.isotr
dc.publisherTurkiye Klinikleri
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectCtla-4 antigen
dc.subjectGenetic
dc.subjectPolymerase chain reaction
dc.subjectPolymorphism
dc.subjectUrinary bladder neoplasms
dc.titleInvestigation of CTLA-4 gene +49 A/G polymorphism in patients with bladder cancer
dc.title.alternativeMesane Kanserli Hastalarda CTLA-4 Geni +49 A/G Polimorfizminin Araştırılması
dc.typeArticle

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