Optimization and modelling of pravastatin recovery from aqueous solutions using reactive extraction methodology

Küçük Resim Yok

Tarih

2024

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Wiley

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

This research endeavour primarily aimed to optimize and establish a model for the recovery of pravastatin, a well-known statin drug recognized for its cholesterol-lowering properties, from aqueous solutions using reactive extraction. This study used the Box-Behnken design to investigate extraction parameters and create a concise model equation illustrating the relationship between variables and responses. The investigation showed a strong agreement between the model equation and experimental outcomes. It highlighted a positive correlation, demonstrating that higher concentrations of reactant and pravastatin led to notable improvements in extraction efficiency. Two out of 90 experiments had extraction efficiencies below 10%, both with constant factors except for solvent type, while 14 experiments exceeding 80% efficiency highlighted the positive impact of a 50% reactant concentration on extraction efficiency. According to a statistical second-order polynomial, the predicted extraction efficiency stands at 75.14%. In the culminating phase of the study, optimal extraction conditions were meticulously determined, resulting in the identification of an optimal set of parameters: a pravastatin concentration of 35 mg center dot L-1, an adogen concentration of 20.91% (v/v), and a butanol phase ratio of 0.2% (v/v). Under optimal conditions, the experimental extraction efficiency reached 72.69%, closely aligning with values predicted through numerical optimization employing response surface methodology.

Açıklama

Anahtar Kelimeler

adogen, Box-Behnken, optimization, pravastatin, reactive extraction

Kaynak

Canadian Journal of Chemical Engineering

WoS Q Değeri

N/A

Scopus Q Değeri

Q2

Cilt

102

Sayı

7

Künye