Optimization and modelling of pravastatin recovery from aqueous solutions using reactive extraction methodology

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dc.authoridYetisen, Mehmet/0000-0001-8347-4081
dc.contributor.authorYetisen, Mehmet
dc.contributor.authorUslu, Hasan
dc.contributor.authorBaltacioglu, Cem
dc.date.accessioned2024-11-07T13:24:14Z
dc.date.available2024-11-07T13:24:14Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThis research endeavour primarily aimed to optimize and establish a model for the recovery of pravastatin, a well-known statin drug recognized for its cholesterol-lowering properties, from aqueous solutions using reactive extraction. This study used the Box-Behnken design to investigate extraction parameters and create a concise model equation illustrating the relationship between variables and responses. The investigation showed a strong agreement between the model equation and experimental outcomes. It highlighted a positive correlation, demonstrating that higher concentrations of reactant and pravastatin led to notable improvements in extraction efficiency. Two out of 90 experiments had extraction efficiencies below 10%, both with constant factors except for solvent type, while 14 experiments exceeding 80% efficiency highlighted the positive impact of a 50% reactant concentration on extraction efficiency. According to a statistical second-order polynomial, the predicted extraction efficiency stands at 75.14%. In the culminating phase of the study, optimal extraction conditions were meticulously determined, resulting in the identification of an optimal set of parameters: a pravastatin concentration of 35 mg center dot L-1, an adogen concentration of 20.91% (v/v), and a butanol phase ratio of 0.2% (v/v). Under optimal conditions, the experimental extraction efficiency reached 72.69%, closely aligning with values predicted through numerical optimization employing response surface methodology.
dc.description.sponsorshipNigde UEniversitesi [TGT 2022/13-LUTEP]
dc.description.sponsorshipNigde UEniversitesi, Grant/Award Number: TGT 2022/13-LUTEP
dc.identifier.doi10.1002/cjce.25201
dc.identifier.endpage2571
dc.identifier.issn0008-4034
dc.identifier.issn1939-019X
dc.identifier.issue7
dc.identifier.scopus2-s2.0-85183836332
dc.identifier.scopusqualityQ2
dc.identifier.startpage2561
dc.identifier.urihttps://doi.org/10.1002/cjce.25201
dc.identifier.urihttps://hdl.handle.net/11480/13992
dc.identifier.volume102
dc.identifier.wosWOS:001152315100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofCanadian Journal of Chemical Engineering
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectadogen
dc.subjectBox-Behnken
dc.subjectoptimization
dc.subjectpravastatin
dc.subjectreactive extraction
dc.titleOptimization and modelling of pravastatin recovery from aqueous solutions using reactive extraction methodology
dc.typeArticle

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