İndol ve türevlerinin michael tipi katılma reaksiyonları
| dc.contributor.advisor | Abdullah, Meysun İbrahim | |
| dc.contributor.author | Daşbaşı, Teslima | |
| dc.date.accessioned | 2024-11-04T20:07:56Z | |
| dc.date.available | 2024-11-04T20:07:56Z | |
| dc.date.issued | 2007 | |
| dc.department | Niğde ÖHÜ, Fen Bilimleri Enstitüsü, Kimya Ana Bilim Dalı | |
| dc.description | Fen Bilimleri Enstitüsü, Kimya Ana Bilim Dalı | |
| dc.description.abstract | Bu çalısmada indol, 1-metil- ve 1,3-dimetilindol'ün K-10 Montmorillonit katalizörü varlıgında alfa,beta-doymamıs karbonil bilesiklerinden metil propiolat ve 2-siklopentenonun Michael tipi katılma tepkimeleri incelenmistir. Bu reaksiyonlardan iyi verimle katılma, bis-, tris-indolil ve halkalasma ürünleri elde edilmistir. ndol ile metilpropiolatın reaksiyonundan bir diindolil bilesigi, metil 3,3-di(1H-indol-3-il) propanoat elde edilmistir. 1-metilindolün metilpropiolat ile reaksiyonundan ise metil 3,3-bis(1-metil- 1H-indol-3-il) propanoat bilesigi sentezlenmistir. Aynı reaktif ile 1,3-dimetilindolün reaksiyonundan sırasıyla; metil 3,3-bis(1,3-dimetil-1H-indol-2-il) propanoat, metil 3,3,3-tris(1,3-dimetil-1H-indol-2-il) propanoat ve metil 1,5-dimetil-1H-benzo[b]azopin- 3-karboksilat halkalasma ürünü elde edilmistir. Ayrıca indol, 1-metil- ve 1,3- dimetilindolün 2-siklopentenon ile reaksiyonları sonucunda sırasıyla; 3-(1H-indol-3-il) siklopentanon bilesigi, 3-(1-metil-1H-indol-3-il) siklopentanon ve 3-(1,2-dimetil-1Hindol- 3-il) siklopentanon katılma ürünleri sentezlenmistir. Anahtar Sözcükler: İndol, Michael Katılma, Kil, Montmorillonit, 2-Siklopentenon, Metilpropiolat | |
| dc.description.abstract | In this work, Micheal type reactions of indole, 1-methyl- and 1,3-dimethylindole with the alfa,beta unsaturated carbonyl methyl propiolate and 2-cyclopentenone in the presence of K-10 Montmorillonit was investigated. These reactions gave addition, cyclization as well as bis- and tris- indolyl products in a good yield. The reaction of indole with methyl propiolate produced the diindolyl methyl 3,3-di(1H-indol-3-yl) propanoate compound while the reaction of N-methyl indole with methyl propiolate gave methyl 3,3-bis(1-methyl-1H-indol-3-yl) propanoate. However, the reaction of 1,3- dimethylindole withe the same reactant yielded methyl 3,3-bis(1,3-dimethyl-1H-indol- 2-yl) propanoate, methyl 3,3,3-tris(1,3-dimethyl-1H-indol-2-yl) propanoate and the cyclic product methyl 1,5-dimethyl-1H-benzo[b]azopine-3-carboxylate repectively. Meanwhile the reaction of indole, 1-methyl- and 1,3-dimethylindole with 2- cyclopentenone gave 3-(1H-indol-3-yl) cyclopentanone, 3-(1-methyl-1H-indol-3-yl) cyclopentanon and the 3-(1,2-dimethyl-1H-indol-3-yl) cyclopentanone addition products respectively. Keywords: ndole, Michael Addition, Clay, Montmorillonite, 2-Cyclopentenone, Methylpropiolate. | |
| dc.identifier.endpage | 94 | |
| dc.identifier.startpage | 1 | |
| dc.identifier.uri | https://tez.yok.gov.tr/UlusalTezMerkezi/TezGoster?key=-Z0vbSUgrhM9fXoGkRe6Q3V582ykLVHtsZBzS04Uustg5ERySsW07XijTxWSBie- | |
| dc.identifier.uri | https://hdl.handle.net/11480/9539 | |
| dc.identifier.yoktezid | 222437 | |
| dc.language.iso | tr | |
| dc.publisher | Niğde Üniversitesi | |
| dc.relation.publicationcategory | Tez | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.snmz | KA_2024 | |
| dc.subject | Kimya | |
| dc.subject | Chemistry | |
| dc.title | İndol ve türevlerinin michael tipi katılma reaksiyonları | |
| dc.title.alternative | Michael type reactions of indole and its derivatives | |
| dc.type | Master Thesis |
