24-year-old Male patient Diagnosed with Intramucosal Signet Ring Cell Gastric Cancer with Molecular Analysis: A Case Report

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dc.contributor.authorEroglu, Mehtap
dc.contributor.authorAkin Bali, Dilara Fatma
dc.contributor.authorAktas, Sedef Hande
dc.contributor.authorKankilic, Teoman
dc.date.accessioned2024-11-07T13:32:06Z
dc.date.available2024-11-07T13:32:06Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractStomach cancer is the third leading cause of death among cancer-related deaths in the world. Signet-ring cell carcinoma (SRCC), a type of gastric adenocarcinoma, is frequently diagnosed in people aged fifty or older, and its incidence increases with age, but SRCC is rare in young age groups. In general, this type of cancer is thought to be more aggressive and has a worse prognosis than other types of gastric cancer. However, there are uncertainties about the characteristics and survival outcomes. Since the diagnostic tools used in patients with SRCC have low sensitivity and specificity in diagnosis and prognosis, it is important to support the diagnosis, follow-up of treatment and relapse with molecular genetic biomarkers. The aim in the current case is to see if TP53, which is the most frequently mutated gene in SRCC and NF1, that is expressed as one of the largest genes in the human genome and classified as a tumor suppressor gene, can be used as a prognostic genetic biomarker in the pathogenesis of early SRCCIt is predicted that P53 may be a determinant factor in the pathogenesis of SRCC due to the mutation burden in this case.
dc.identifier.doi10.5505/tjo.2019.2100
dc.identifier.endpage224
dc.identifier.issn1300-7467
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85088494378
dc.identifier.scopusqualityQ4
dc.identifier.startpage218
dc.identifier.trdizinid377448
dc.identifier.urihttps://doi.org/10.5505/tjo.2019.2100
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/377448
dc.identifier.urihttps://hdl.handle.net/11480/15234
dc.identifier.volume35
dc.identifier.wosWOS:000537954700016
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherKare Publ
dc.relation.ispartofTurk Onkoloji Dergisi-Turkish Journal of Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectGastric cancer
dc.subjectNF1
dc.subjectsignet ring cell gastric cancer
dc.subjectTP53
dc.title24-year-old Male patient Diagnosed with Intramucosal Signet Ring Cell Gastric Cancer with Molecular Analysis: A Case Report
dc.typeArticle

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