ADENOSINE DEAMINASE ACTIVITY IN PATIENTS WITH ANKYLOSING SPONDYLITIS

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dc.contributor.authorGüntürk, İnayet
dc.contributor.authorErsoy, Emre
dc.contributor.authorSeyde, Gonul Seyda
dc.contributor.authorErşan, Serpil
dc.contributor.authorSari, İsmail
dc.contributor.authorYazıcı, Cevat
dc.contributor.authorKöse, Kader
dc.date.accessioned2024-11-07T13:19:11Z
dc.date.available2024-11-07T13:19:11Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAlthough the pathogenesis of ankylosing spondylitis (AS), which is a systemic disease characterized by inflammation, is largely unknown, pro-inflammatory mediators, oxidative stress, and immunity are thought to be involved in the development and the prognosis of the disease. It was aimed in this study to reveal activities of adenosine deaminase (ADA), a cornerstone enzyme in different pathways. Twenty nine AS patients and 16 healthy volunteers were included in the study. Patients were divided into two groups as active and inactive phases. Additionally, the patients were re-grouped according to axial/peripheral involvement. ADA and myeloperoxidase (MPO) activities, and advanced oxidation protein products (AOPP) levels were measured in plasma of the study groups. While the significant increases were observed in AOPP and MPO levels in AS patients compared to the control group, when the patients were divided into subgroups, only ADA was significantly decreased in active patients. On the other hand, there was no significant difference in AOPP, MPO, and ADA levels in groups created according to axial/peripheral involvement. Based on these findings, it is thought that the decrease in ADA levels in AS patients can give an idea about the prognosis of the disease and can be used as an activity marker. Keywords: Adenosine deaminase, advanced oxidation protein products, ankylosing spondylitis, autoinflammation, myeloperoxidase.
dc.identifier.doi10.34108/eujhs.1073877
dc.identifier.endpage286
dc.identifier.issn1018-3655
dc.identifier.issn1018-3655
dc.identifier.issue3
dc.identifier.startpage282
dc.identifier.trdizinid1157826
dc.identifier.urihttps://doi.org/10.34108/eujhs.1073877
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1157826
dc.identifier.urihttps://hdl.handle.net/11480/12947
dc.identifier.volume31
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofSağlık Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241107
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectGenel ve Dahili Tıp
dc.subjectSağlık Bilimleri ve Hizmetleri
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.subjectRomatoloji
dc.subjectMyeloperoxidase
dc.subjectAdenosine Deaminase
dc.subjectAdvanced Oxidation Protein Products
dc.subjectAnkylosing Spondilitis
dc.subjectAutoinflammation
dc.titleADENOSINE DEAMINASE ACTIVITY IN PATIENTS WITH ANKYLOSING SPONDYLITIS
dc.typeArticle

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