Histopathological Analysis of The Eye And Optic Nerve Structure In The Blind Mole Rat

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dc.contributor.authorKeleş, Ayşe İkinci
dc.contributor.authorSüt, Burcu
dc.contributor.authorKankılıc, Teoman
dc.date.accessioned2024-11-07T13:19:34Z
dc.date.available2024-11-07T13:19:34Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjective: Blind mole rats (Nannospalax xanthodon Nehring, 1898) are subterranean mammals that are well-known fortheir high tolerance to hypoxia and resistance to cancer. Due to their unusual habitat, these animals have developedseveral adaptations during their evolution. Therefore, this study aimed to identify possible structural differences inNannospalax visual system in comparison to other mammals that might have arisen as a result of adaptation tounderground life.Method: Six blind mole rats were used in the study. No procedure was performed on the rats. After the animals wereanesthetized with ether, their eyes and optic nerves were removed. For this purpose, pseudo-eyes and optic nerves wereharvested and fixed in 10% formaldehyde for a week. Tissues were embedded into paraffin and blocked via routinehistological procedures. Five micrometer sections in thickness were taken and stained with Hematoxylin & Eosin (H&E)and Cresyl Violet.Results: Histopathological analysis of the eye revealed the presence of cornea, retina, sclera, iris, zonula adherens,lacrimal gland and ducts, fatty tissue, muscle layer and the vascular structures. No pathology was observed of optic nerve.Conclusions: We found that the visual system of N. xanthodon share some similarities with other blind mole rat speciesfrom Israel, while some histological properties were defined by our study for the first time in the literature.
dc.identifier.doi10.5798/dicletip.800025
dc.identifier.endpage644
dc.identifier.issn1300-2945
dc.identifier.issn1308-9889
dc.identifier.issue3
dc.identifier.startpage638
dc.identifier.trdizinid365111
dc.identifier.urihttps://doi.org/10.5798/dicletip.800025
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/365111
dc.identifier.urihttps://hdl.handle.net/11480/13180
dc.identifier.volume47
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofDicle Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241107
dc.subjectBiyoloji
dc.subjectOptik
dc.subjectPatoloji
dc.subjectGöz Hastalıkları
dc.subjectZooloji
dc.titleHistopathological Analysis of The Eye And Optic Nerve Structure In The Blind Mole Rat
dc.typeArticle

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