Effects of Pentylenetetrazol-Induced Kindling on Mature and Immature Rat Behavior, Emotional Learning, and Nitric Oxide Level in Brain and Serum

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dc.contributor.authorGol, Mehmet Fatih
dc.contributor.authorErdogan, Fusun Ferda
dc.contributor.authorKanan, Derya Deniz
dc.contributor.authorKanbur, Murat
dc.contributor.authorGolgeli, Asuman
dc.contributor.authorOzturk, Ahmet
dc.date.accessioned2024-11-07T13:25:25Z
dc.date.available2024-11-07T13:25:25Z
dc.date.issued2019
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjectives:This aim of this study was to investigate emotional memory-learning and behavioral functions, as well as the relationship between these functions and the nitric oxide (NO) level in the serum and brain of mature and immature rats following pentylenetetrazol (PTZ)-induced kindling. Methods: A total of 36 male Wistar albino rats were included in the study. Kindling was induced by repeated injections of a subconvulsive dose of PTZ (30 mg/kg) on alternate days until kindling development.The rats were tested using an elevated T-maze and an open-field test after PTZ kindling. Brain and serum NO levels were assessed. Results: Although both mature and immature rats were susceptible to PTZ-induced seizures, the mature rats had seizures of longer duration than the immature rats, with the exception of infants. There was no demonstrated effect of PTZ-kindling on emotional memory and learning functions in any of the rats. Anxiety levels were low in the mature-kindled rats but were high in the immature-kindled rats. NO levels in the brain were elevated and anxiety reactions were below normal in the mature rats. In immature rats, however, NO levels were normal, but anxiety reactions were elevated. Conclusion: Seizure susceptibility, emotional responses, and the relationship between these factors and brain NO level after PTZ-kindling differed in rats based on brain maturity status.
dc.identifier.doi10.14744/epilepsi.2018.73745
dc.identifier.endpage58
dc.identifier.issn1300-7157
dc.identifier.issue2
dc.identifier.startpage51
dc.identifier.trdizinid311842
dc.identifier.urihttps://doi.org/10.14744/epilepsi.2018.73745
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/311842
dc.identifier.urihttps://hdl.handle.net/11480/14688
dc.identifier.volume25
dc.identifier.wosWOS:000474456600003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isotr
dc.publisherKare Publ
dc.relation.ispartofEpilepsi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectBehavior
dc.subjectemotional memory-learning
dc.subjectnitric oxide
dc.subjectpentylenetetrazol kindling
dc.titleEffects of Pentylenetetrazol-Induced Kindling on Mature and Immature Rat Behavior, Emotional Learning, and Nitric Oxide Level in Brain and Serum
dc.typeArticle

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