Evaluation of Gold Nanoparticles in Terms of Their Use in Biomedical Applications
Küçük Resim Yok
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Recently nanotechnology has become an integral part of modern biomedical applications.Accordingly, nanoparticles are considered as promising components for the development ofinnovative tags, probes, biosensors and carrier molecules for drug delivery. Spherical colloidal goldnanoparticles (AuNPs) are prime candidates to be utilized for these purposes due to their usefulphysical properties. However, in order for the gold nanoparticles to be used in nanomedicine, theirbiological properties should be extensively studied as well. Therefore, in this paper we chemicallysynthesized gold nanoparticles and studied their physical and biological characteristics to determinetheir potential use in medicine. Gold nanoparticles were synthesized by the reduction of chloroauricacid (HAuCl4) solution with sodium citrate. The physical properties of the AuNPs were determinedby UV–vis spectrophotometer and Zetasizer readings. The antimicrobial activity of the newlysynthesized gold nanoparticles on Escherichia coli, Salmonella infantis, Salmonella kentucky,Salmonella typhimurium, Salmonella enteritidis, Pseudomonas aeruginosa, Listeriamonocytogenes, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis,Bacillus subtilis and Candida albicans were investigated via disk diffusion method. We found thatthe AuNPs were monodisperse, stable and not prone to aggregation with an average size of 22.12nm and an emission band at 522 nm. The disk diffusion tests revealed that the gold nanoparticles didnot have a significant growth inhibitory effect on the pathogens tested. In conclusion, here weshowed the successful synthesis of gold nanoparticles by a safe and non-toxic method. Furthermore,our evaluation of the antimicrobial activity of these nanoparticles suggests that these molecules couldbe considered as biologically safe molecules for future medical applications.
Açıklama
Anahtar Kelimeler
Biyoloji, Mühendislik, Biyotıp, Nanobilim ve Nanoteknoloji, Mikrobiyoloji, Biyoteknoloji ve Uygulamalı Mikrobiyoloji, Malzeme Bilimleri, Biyomalzemeler
Kaynak
Türk Tarım - Gıda Bilim ve Teknoloji dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
7
Sayı
10
