Evaluation of Gold Nanoparticles in Terms of Their Use in Biomedical Applications

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dc.contributor.authorSüt, Burcu
dc.contributor.authorCanpolat, Elif
dc.date.accessioned2024-11-07T13:16:25Z
dc.date.available2024-11-07T13:16:25Z
dc.date.issued2019
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractRecently nanotechnology has become an integral part of modern biomedical applications.Accordingly, nanoparticles are considered as promising components for the development ofinnovative tags, probes, biosensors and carrier molecules for drug delivery. Spherical colloidal goldnanoparticles (AuNPs) are prime candidates to be utilized for these purposes due to their usefulphysical properties. However, in order for the gold nanoparticles to be used in nanomedicine, theirbiological properties should be extensively studied as well. Therefore, in this paper we chemicallysynthesized gold nanoparticles and studied their physical and biological characteristics to determinetheir potential use in medicine. Gold nanoparticles were synthesized by the reduction of chloroauricacid (HAuCl4) solution with sodium citrate. The physical properties of the AuNPs were determinedby UV–vis spectrophotometer and Zetasizer readings. The antimicrobial activity of the newlysynthesized gold nanoparticles on Escherichia coli, Salmonella infantis, Salmonella kentucky,Salmonella typhimurium, Salmonella enteritidis, Pseudomonas aeruginosa, Listeriamonocytogenes, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis,Bacillus subtilis and Candida albicans were investigated via disk diffusion method. We found thatthe AuNPs were monodisperse, stable and not prone to aggregation with an average size of 22.12nm and an emission band at 522 nm. The disk diffusion tests revealed that the gold nanoparticles didnot have a significant growth inhibitory effect on the pathogens tested. In conclusion, here weshowed the successful synthesis of gold nanoparticles by a safe and non-toxic method. Furthermore,our evaluation of the antimicrobial activity of these nanoparticles suggests that these molecules couldbe considered as biologically safe molecules for future medical applications.
dc.identifier.doi10.24925/turjaf.v7i10.1694-1698.2815
dc.identifier.endpage1698
dc.identifier.issn2148-127X
dc.identifier.issue10
dc.identifier.startpage1694
dc.identifier.trdizinid355203
dc.identifier.urihttps://doi.org/10.24925/turjaf.v7i10.1694-1698.2815
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/355203
dc.identifier.urihttps://hdl.handle.net/11480/12291
dc.identifier.volume7
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTürk Tarım - Gıda Bilim ve Teknoloji dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241107
dc.subjectBiyoloji
dc.subjectMühendislik
dc.subjectBiyotıp
dc.subjectNanobilim ve Nanoteknoloji
dc.subjectMikrobiyoloji
dc.subjectBiyoteknoloji ve Uygulamalı Mikrobiyoloji
dc.subjectMalzeme Bilimleri
dc.subjectBiyomalzemeler
dc.titleEvaluation of Gold Nanoparticles in Terms of Their Use in Biomedical Applications
dc.typeArticle

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