The Anticancer Activity of Cetraria Islandica (L.) Ach in Breast Cancer Cells Through Crosstalk of Ampk-?1 and Erk1/2 Signalling

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dc.contributor.authorGüven, Celal
dc.contributor.authorGüven, Eylem Taşkın
dc.contributor.authorYumrutaş, Önder
dc.contributor.authorŞener, Leyla Türker
dc.contributor.authorÖzay, Yusuf
dc.contributor.authorDal, Fulya
dc.contributor.authorAhbab, Mufide
dc.date.accessioned2024-11-07T13:16:25Z
dc.date.available2024-11-07T13:16:25Z
dc.date.issued2018
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractIn the present study, we aimed to evaluate the anticancer activities of Cetraria islandica(C.islandica) extracts on MCF-7 breast cancer cell lines. Cell viability, protein levels,apoptotic cells number, F-actin distribution were measured. Cell viability of MCF-7breast cancer cells was found to be reduced in a dose-dependent manner.EC50 values ofC.islandica on MCF-7 cells were found to be 9.2047 E-5 g/ml (cell amount) by usingintelligence system. Expressions of p53, caspase 3 and Bcl-2, were shown to be elevatedafter low doses of extract and diminished after high dose treatments. PPAR-? proteinlevel was decreased, although AMP-activated kinases-?1 (AMPK-?1) protein level wasincreasedin its extract groups. ERK1/2 protein level was also elevated in its extractgroups. 125 mg/ml of extract treated cells show a low decrease in actin filament density.MCF-7 cells with C.islandica treatment for 24 h increased the apoptotic cell percentage,though the cells-treated with C.islandica for 48 was high necrotic cells percentage.Consequently, the C.islandica extract treatment causes to elevate ERK1/2 and AMPK-?1protein levels, resulting in PPAR-? and then triggers the apoptosis by modulationcaspase-3 and P53 protein levels. Therefore, C.islandica might be a good candidate foranticancer tissue, especially soft tissue tumours.
dc.identifier.doi10.24925/turjaf.v6i6.783-791.1940
dc.identifier.endpage791
dc.identifier.issn2148-127X
dc.identifier.issue6
dc.identifier.startpage783
dc.identifier.trdizinid328283
dc.identifier.urihttps://doi.org/10.24925/turjaf.v6i6.783-791.1940
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/328283
dc.identifier.urihttps://hdl.handle.net/11480/12281
dc.identifier.volume6
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTürk Tarım - Gıda Bilim ve Teknoloji dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241107
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectOnkoloji
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.titleThe Anticancer Activity of Cetraria Islandica (L.) Ach in Breast Cancer Cells Through Crosstalk of Ampk-?1 and Erk1/2 Signalling
dc.typeArticle

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