The effect of boric acid on copine-7 expression and bioactivity in dental pulp stem cells

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dc.contributor.authorBozkurt, Serife Buket
dc.contributor.authorHakki, Sema S.
dc.date.accessioned2024-11-07T10:40:09Z
dc.date.available2024-11-07T10:40:09Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBoron has significant impact on the mineral composition of teeth. Copine-7 (Cpne-7) is secreted by pre-ameloblasts and induces dentin formation via differentiation of mesenchymal cells of dental. The goal of this study was to see how boric acid affected the bioactivity and expression of Cpne-7, collagen type I in dental pulp stem cell. The expression of Cpne-7, COL-I were assessed in the boric acid treated pulp cells by molecular method on 3 and 8 days exposure. When comparing the different boric acid concentrations to the control group in a proliferation experiment, no significant differences were noted. At 10 ng/mL boric acid, a rise in the number of mineralized nodules was observed. Boric acid concentrations (1 ng/mL, 10 ng/mL) increased the transcripts of Cpne-7 on day 3 and 8. Additionally, 1 ng/ mL boric acid concentration significantly upregulated of Cpne-7 expression compared to control group on day 3 and 8. When the 1-10 ng boric acid was compared to control group COL-I expression remarkably enhanced in cell. According to the current findings that boric acid may be a potent regulator of Cpne-7, which is a promising candidate for new dentin formation in regenerative dentistry, in dental pulp stem cells and provide osteogenic efficacy in therapies aimed at dentin formation. © 2022, Turkish Energy Nuclear and Mining Research Institute. All rights reserved.
dc.identifier.doi10.30728/boron.1069145
dc.identifier.endpage466
dc.identifier.issn2149-9020
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85187902580
dc.identifier.scopusqualityN/A
dc.identifier.startpage461
dc.identifier.trdizinid1140664
dc.identifier.urihttps://doi.org/10.30728/boron.1069145
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1140664
dc.identifier.urihttps://hdl.handle.net/11480/11457
dc.identifier.volume7
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTurkish Energy Nuclear and Mining Research Institute
dc.relation.ispartofJournal of Boron
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectBoric acid
dc.subjectCpne-7
dc.subjectPulp mesenchymal stem cells
dc.titleThe effect of boric acid on copine-7 expression and bioactivity in dental pulp stem cells
dc.typeArticle

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