Neuroprotective Effects of Oleocanthal, a Compound in Virgin Olive Oil, in a Rat Model of Traumatic Brain Injury

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dc.authoridunsal, ulkun unlu/0000-0001-5194-3138
dc.authoridAYDEMIR, ISIL/0000-0002-4143-7319
dc.contributor.authorMete, Mesut
dc.contributor.authorAydemir, Isil
dc.contributor.authorUnsal, Ulkun Unlu
dc.contributor.authorCollu, Fatih
dc.contributor.authorVatandas, Gokhan
dc.contributor.authorGurcu, Beyhan
dc.contributor.authorDuransoy, Yusuf Kurtulus
dc.date.accessioned2024-11-07T13:34:50Z
dc.date.available2024-11-07T13:34:50Z
dc.date.issued2018
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAIM: To evaluate the neuroprotective effects of deocanthal OC in a rat model of traumatic brain injury (TBI). MATERIAL and METHODS: Twenty-six adult male, Wistar albino rats were used. The rats were divided into 4 groups. Group 1 was the sham group (n=5). Group 2 was the trauma group (n=5) where rats were treated with 10 mg/kg saline intraperitoneally (IP) twice a day. Groups 3 and 4, rats were treated with 10 (group 3, n=8) or 30 (group 4, n=8) mg/kg OC IP twice a day. For each group, brain samples were collected 72 hours after injury. Brain samples and blood were evaluated with histopathological and biochemical methods. RESULTS: Histopathological evaluation revealed a significant difference between Group 2 and Group 4. Biochemical findings demonstrated that the oxidative stress index was highest in Group 2 and lowest in Group 4. CONCLUSION: OC has a protective effect on neural cells after TBI. This effect is achieved by reducing oxidative stress and apoptosis.
dc.description.sponsorshipTurkish Neurosurgical Society
dc.description.sponsorshipPreparation for publication of this article was partly supported by the Turkish Neurosurgical Society.
dc.identifier.doi10.5137/1019-5149.JTN.21417-17.2
dc.identifier.endpage865
dc.identifier.issn1019-5149
dc.identifier.issue6
dc.identifier.pmid29204981
dc.identifier.scopus2-s2.0-85057158991
dc.identifier.scopusqualityQ3
dc.identifier.startpage858
dc.identifier.trdizinid299620
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.21417-17.2
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/299620
dc.identifier.urihttps://hdl.handle.net/11480/16185
dc.identifier.volume28
dc.identifier.wosWOS:000450653000002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neurosurgical Soc
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectApoptosis
dc.subjectNeuroprotection
dc.subjectOleocanthal
dc.subjectRat
dc.subjectTraumatic brain injury
dc.titleNeuroprotective Effects of Oleocanthal, a Compound in Virgin Olive Oil, in a Rat Model of Traumatic Brain Injury
dc.typeArticle

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