Hepatoprotective effect of royal jelly, grape seed extract, and Lycium barbarum against diethylnitrosamine-induced liver toxicity in rats
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: We aimed to investigate, the effects of royal jelly (RJ), grape seed extract (GSE), and Lycium barbarum extract (LBAE) against diethylnitrosamine (DEN) induced hepatotoxicity, in experimental animal model. Material and Methods: Fifty female Sprague Dawley rats were divided into five groups (n=10): Control, DEN, DEN+RJ, DEN+GSE, DEN+LBAE. DEN administrated groups were intraperitoneally (i.p.) injected with three separate administration of DEN (200 mg/kg), on the zero, fifteenth and thirtieth treatment day. Then 100 mg/kg of RJ was given to DEN+RJ group, 100 mg/kg of GSE was given to DEN+GSE group, and 400 mg/kg LBAE was given to DEN+LBAE group with the daily drinking water from day 0 for 16 weeks. Histopathologic alterations including apoptotic changes of liver were evaluated. Results: RJ, GSE, and LBAE treatments significantly reduced weight loss induced by DEN. DEN administrated rats significantly increases malondialdehyde (MDA) level. It also efficiently decreases glutathione (GSH) level and catalase (CAT), superoxide dismutase (SOD) activity. These results were significantly ameliorated by dietary supplements (p<0.05). In addition, they increased the total antioxidant status (TAS) level and decreased serum oxidative stress index (OSI), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma glutamyl transpeptidase (GGT) levels significantly (p<0.05). TUNEL positive cells were extremly pervasive in the livers of DEN group. Conclusion: Improvements were prominent in case of RJ > GSE > LBAE. Our results indicated that RJ, GSE and LBAE might be useful for prevention of hepatotoxicity induced by DEN via ameliorative effects on biochemical and oxidative stress indices.
Açıklama
Anahtar Kelimeler
Biyokimya ve Moleküler Biyoloji, Anatomi ve Morfoloji, Periferal Damar Hastalıkları, Kalp ve Kalp Damar Sistemi, Solunum Sistemi, İmmünoloji, Dermatoloji, Göz Hastalıkları, Patoloji, Klinik Nöroloji, Odyoloji ve Konuşma-Dil Patolojisi, Nörolojik Görüntüleme, Radyoloji, Nükleer Tıp, Tıbbi Görüntüleme, Acil Tıp, Transplantasyon, Enfeksiyon Hastalıkları, Halk ve Çevre Sağlığı, Tıbbi İnformatik, Geriatri ve Gerontoloji, Nörolojik Bilimler, Hematoloji, Tıbbi Laboratuar Teknolojisi, Adli Tıp, Tıbbi Etik, Kadın Hastalıkları ve Doğum, Gastroenteroloji ve Hepatoloji, Temel Sağlık Hizmetleri, Cerrahi, Hücre Biyolojisi, Ortopedi, Genel ve Dahili Tıp, Pediatri, Tamamlayıcı ve Entegre Tıp, Sağlık Bilimleri ve Hizmetleri, Biyokimyasal Araştırma Metotları, Kulak, Burun, Boğaz, Tıbbi Araştırmalar Deneysel, Psikiyatri, Biyofizik, Yoğun Bakım, Tıp, Fizyoloji, Endokrinoloji ve Metabolizma, Androloji, Biyoteknoloji ve Uygulamalı Mikrobiyoloji, Gelişim Biyolojisi, Gerontoloji, Anestezi, Rehabilitasyon, Onkoloji, Mikrobiyoloji, Spor Bilimleri, Alerji, Tropik Tıp, Üroloji ve Nefroloji, Romatoloji
Kaynak
Annals of Medical Research
WoS Q Değeri
Scopus Q Değeri
Cilt
25
Sayı
3
